Antioxidative and prooxidative effects of quercetin on A549 cells
Quercetin, a common plant polyphenol, has been reported to show both antioxidant and prooxidant properties. We studied the effects of quercetin on A549 cells in in vitro culture. We found that low concentrations of the flavonoid stimulated cell proliferation and increased total antioxidant capacity...
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Published in | Cell biology international Vol. 31; no. 10; pp. 1245 - 1250 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Elsevier Ltd
01.10.2007
Blackwell Publishing Ltd |
Subjects | |
Online Access | Get full text |
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Summary: | Quercetin, a common plant polyphenol, has been reported to show both antioxidant and prooxidant properties. We studied the effects of quercetin on A549 cells in
in vitro culture. We found that low concentrations of the flavonoid stimulated cell proliferation and increased total antioxidant capacity (TAC) of the cells; while higher concentrations of the flavonoid decreased cell survival and viability, thiol content, TAC and activities of superoxide dismutase, catalase and glutathione
S-transferase. Quercetin decreased production of reactive oxygen species in the cells but produced peroxides in the medium. The cellular effects of quercetin are therefore complex and include both antioxidant effects and induction of oxidative stress due to formation of reactive oxygen species in the extracellular medium. |
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Bibliography: | istex:222989F3CC01EA9C6693A1DC4576C5D5E10E6ED9 ark:/67375/WNG-4CD6LTRB-H ArticleID:CBIN1793 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1065-6995 1095-8355 |
DOI: | 10.1016/j.cellbi.2007.04.009 |