碳纳米管/聚吡咯修饰电极用于液相色谱测定帕金森大鼠脑中神经递质
制备了碳纳米管/聚吡咯复合修饰电极,研究了多巴胺等单胺类神经递质在该修饰电极上的电化学行为。将此修饰电极作为电化学检测器,与高效液相色谱联用,测定了脑中7种神经递质及其代谢产物。结果表明：去甲肾上腺素、肾上腺素、多巴胺和5-羟色胺的线性范围为5.0＂10-10～1.0×10-5 mol/L;3,4-二羟基苯乙酸,5-羟吲哚乙酸和高香草酸的线性范围为1.0×10-9～5.0×10-4 mol/L;7种物质相关系数均大于0.998;检出限在0.1 nmol/L水平。结合微透析活体取样,测定了自由活动帕金森模型组大鼠脑纹状体中7种单胺类神经递质及其代谢产物的含量,较正常组有所降低。...
Saved in:
| Published in | 分析化学 Vol. 39; no. 7; pp. 1071 - 1076 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
南京理工大学化工学院,南京,210094
2011
温州医学院药学院化学教研室,温州,325035%温州医学院药学院化学教研室,温州,325035%南京理工大学化工学院,南京,210094 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-3820 |
| DOI | 10.3724/SP.J.1096.2011.01071 |
Cover
| Abstract | 制备了碳纳米管/聚吡咯复合修饰电极,研究了多巴胺等单胺类神经递质在该修饰电极上的电化学行为。将此修饰电极作为电化学检测器,与高效液相色谱联用,测定了脑中7种神经递质及其代谢产物。结果表明：去甲肾上腺素、肾上腺素、多巴胺和5-羟色胺的线性范围为5.0＂10-10～1.0×10-5 mol/L;3,4-二羟基苯乙酸,5-羟吲哚乙酸和高香草酸的线性范围为1.0×10-9～5.0×10-4 mol/L;7种物质相关系数均大于0.998;检出限在0.1 nmol/L水平。结合微透析活体取样,测定了自由活动帕金森模型组大鼠脑纹状体中7种单胺类神经递质及其代谢产物的含量,较正常组有所降低。 |
|---|---|
| AbstractList | R742.5%R329; 制备了碳纳米管/聚吡咯复合修饰电极,研究了多巴胺等单胺类神经递质在该修饰电极上的电化学行为.将此修饰电极作为电化学检测器,与高效液相色谱联用,测定了脑中7种神经递质及其代谢产物.结果表明:去甲肾上腺素、肾上腺素、多巴胺和5-羟色胺的线性范围为5.0×10(-10)～1.0×10(-5)mol/L;3,4-二羟基苯乙酸,5-羟吲哚乙酸和高香草酸的线性范围为1.0×10(9)～5.0×10(-4)mol/L;7种物质相关系数均大于0.998;检出限在0.1 nmol/L水平.结合微透析活体取样,测定了自由活动帕金森模型组大鼠脑纹状体中7种单胺类神经递质及其代谢产物的含量,较正常组有所降低. 制备了碳纳米管/聚吡咯复合修饰电极,研究了多巴胺等单胺类神经递质在该修饰电极上的电化学行为。将此修饰电极作为电化学检测器,与高效液相色谱联用,测定了脑中7种神经递质及其代谢产物。结果表明：去甲肾上腺素、肾上腺素、多巴胺和5-羟色胺的线性范围为5.0＂10-10～1.0×10-5 mol/L;3,4-二羟基苯乙酸,5-羟吲哚乙酸和高香草酸的线性范围为1.0×10-9～5.0×10-4 mol/L;7种物质相关系数均大于0.998;检出限在0.1 nmol/L水平。结合微透析活体取样,测定了自由活动帕金森模型组大鼠脑纹状体中7种单胺类神经递质及其代谢产物的含量,较正常组有所降低。 |
| Author | 林丽 余莉 林瑞泼 李雪燕 杨树林 李校堃 |
| AuthorAffiliation | 南京理工大学化工学院,南京210094 温州医学院药学院化学教研室,温州325035 |
| AuthorAffiliation_xml | – name: 南京理工大学化工学院,南京,210094;温州医学院药学院化学教研室,温州,325035%温州医学院药学院化学教研室,温州,325035%南京理工大学化工学院,南京,210094 |
| Author_FL | LI Xue-Yan LIN Li YU Li YANG Shu-Lin Li Xiao-Kun LIN Rui-Po |
| Author_FL_xml | – sequence: 1 fullname: LIN Li – sequence: 2 fullname: YU Li – sequence: 3 fullname: LIN Rui-Po – sequence: 4 fullname: LI Xue-Yan – sequence: 5 fullname: YANG Shu-Lin – sequence: 6 fullname: Li Xiao-Kun |
| Author_xml | – sequence: 1 fullname: 林丽 余莉 林瑞泼 李雪燕 杨树林 李校堃 |
| BookMark | eNotkEtLAlEcxe_CIDO_QZsWLZ3uc-bOMqQnQkHuWsg4DzVqLCWyXUIQEVSKbQwkK8lNk48MsaAv48wdv0UTtjqL8zvnz__MgZCdt00AFhCUiILp8u6OtCUhqMoShghJEEEFhUAYYkZihGM4C6LFYi4NAxNSzngY7Imnvhj1RbcvnOayX667d023-j7-cSatjqgNvEZZ1Nrj0Y332RMPQ_-q53e63uDaderu8H5yWfGeHffldfL96F9UxsM30WqIr9vJedX_aM-DGUs7KJrRf42A5NpqMr4RS2yvb8ZXEjGdyShGiIqwidOUUdWiEDGV6wq2ZJMacppzjaiMG8zQDcqwbKgQI8j14DOuKgwpskwiYGlae6rZlmZnUvv5k4IdHExZpWzpbwioBKmAW5xyejZvZ45zAXlUyB1qhbMU4RSrVMbkFwcogDo |
| ClassificationCodes | R742.5%R329 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP ~WA 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3724/SP.J.1096.2011.01071 |
| DatabaseName | 维普_期刊 中文科技期刊数据库-CALIS站点 中文科技期刊数据库-7.0平台 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| DocumentTitleAlternate | Liquid Chromatography with Electrochemical Detection Using Multi-wall Carbon Nanotubes/Polypyrrole Composite Film Modified Electrode for in Vivo Analysis of Monoamine Neurotransmitters in Rat Striatal Microdialysate of Freely Moving Parkinsonian Rats |
| DocumentTitle_FL | Liquid Chromatography with Electrochemical Detection Using Multi-wall Carbon Nanotubes/Polypyrrole Composite Film Modified Electrode for in Vivo Analysis of Monoamine Neurotransmitters in Rat Striatal Microdialysate of Freely Moving Parkinsonian Rats |
| EndPage | 1076 |
| ExternalDocumentID | fxhx201107021 38429462 |
| GrantInformation_xml | – fundername: 浙江省自然科学基金; 浙江省医药卫生科技计划项目; 温州市科技局基金 funderid: (Y2100488); (2010QNA015); (Y20090024) |
| GroupedDBID | --K --M .~1 0R~ 1B1 1~. 1~5 29B 2B. 2C. 2RA 4.4 457 4G. 5GY 5VS 7-5 71M 8P~ 92E 92I 92L AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AAXUO ABFNM ABMAC ABXDB ABYKQ ACDAQ ACGFS ACNNM ACRLP ADBBV ADECG ADEZE ADMUD AEBSH AEKER AENEX AFKWA AFTJW AFZHZ AGHFR AGUBO AGYEJ AIEXJ AIKHN AITUG AJBFU AJOXV AJSZI ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC CQIGP CS3 CW9 DU5 EBS EFJIC EFLBG EJD EO9 EP2 EP3 FDB FEDTE FIRID FLBIZ FNPLU FYGXN GBLVA HVGLF HZ~ J1W KOM M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 ROL SDF SDG SES SPC SPCBC SSK SSZ T5K TCJ TGP U1G U5L ~G- ~WA -02 -0B -SB -S~ .5D 188 4A8 5VR 5XA 5XC 8RM 92M 93N 9D9 9DB AAITT AATTM AAXKI AAYWO ABJNI ABWVN ACRPL ADNMO ADVLN AEIPS AFJKZ AFUIB AFXIZ AGCQF AGRNS AIIUN AKRWK ANKPU APXCP BBR BNPGV CAJEB CCEZO CDRFL CDYEO CJPJV CW7 FA0 J.9 JUIAU M~T PB1 PB6 PSX Q-- R-B RT2 S.. SSH T8R U1F U5B UY8 UZ4 W94 ~LN |
| ID | FETCH-LOGICAL-c561-33912e2b4549f401598c72f6e4d6b88a3958d5dcd4526d902108c010897517663 |
| ISSN | 0253-3820 |
| IngestDate | Thu May 29 04:00:21 EDT 2025 Wed Feb 14 09:50:34 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Keywords | 微渗析活体取样 液相色谱电化学检测 碳纳米管/聚吡咯复合修饰电极 神经递质 帕金森病 |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c561-33912e2b4549f401598c72f6e4d6b88a3958d5dcd4526d902108c010897517663 |
| Notes | Multi-wall carbon nanotube/polypyrrole composite film modified electrode; High performance liquid chromatography with electrochemical detection; In vivo microdialysis; Monoamine neurotransmitters; Parkinson′s disease A multi-wall carbon nanotubes/polypyrrole modified electrode that can be used as the working electrode in the high performance liquid chromatography with electrochemical detection to determine the monoamine neurotransmitters was developed.The voltammetric response of dopamine could be promoted by using the electrode.The peak currents of norepinephrine,epinephrine,dopamine and 5-hydroxytryptamine were linear with their concentrations ranging from 5.0×10-10 to 1.0×10-5 mol/L,and the peak currents of 3,4-dihydroxyphenylacetic acid,5-hydroxyindoleacetic acid and homovanillic acid were linear with their concentrations ranging from 1.0×10-9 to 5.0×10-4 mol/L.The correlation coefficients of the seven compounds were more than 0.998.The detection limits were the level of 0.1 nmol/L.Coupled with in vivo mic |
| PageCount | 6 |
| ParticipantIDs | wanfang_journals_fxhx201107021 chongqing_primary_38429462 |
| PublicationCentury | 2000 |
| PublicationDate | 2011 |
| PublicationDateYYYYMMDD | 2011-01-01 |
| PublicationDate_xml | – year: 2011 text: 2011 |
| PublicationDecade | 2010 |
| PublicationTitle | 分析化学 |
| PublicationTitleAlternate | Chinese Journal of Analytical Chemistry |
| PublicationTitle_FL | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY |
| PublicationYear | 2011 |
| Publisher | 南京理工大学化工学院,南京,210094 温州医学院药学院化学教研室,温州,325035%温州医学院药学院化学教研室,温州,325035%南京理工大学化工学院,南京,210094 |
| Publisher_xml | – name: 南京理工大学化工学院,南京,210094 – name: 温州医学院药学院化学教研室,温州,325035%温州医学院药学院化学教研室,温州,325035%南京理工大学化工学院,南京,210094 |
| SSID | ssib001104858 ssib048394981 ssj0037577 ssib002258198 ssib007686865 ssib051370160 |
| Score | 1.8729392 |
| Snippet | 制备了碳纳米管/聚吡咯复合修饰电极,研究了多巴胺等单胺类神经递质在该修饰电极上的电化学行为。将此修饰电极作为电化学检测器,与高效液相色谱联用,测定了脑中7种神经递质及其代谢产物。结果表明：去甲肾上腺素、肾上腺素、多巴胺和5-羟色胺的线性范围为5.0＂10-10～1.0×10-5... R742.5%R329;... |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 1071 |
| SubjectTerms | 帕金森病 微渗析活体取样 液相色谱电化学检测 碳纳米管/聚吡咯复合修饰电极 神经递质 |
| Title | 碳纳米管/聚吡咯修饰电极用于液相色谱测定帕金森大鼠脑中神经递质 |
| URI | http://lib.cqvip.com/qk/93919X/201107/38429462.html https://d.wanfangdata.com.cn/periodical/fxhx201107021 |
| Volume | 39 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR1Na9RANNR60Iv4ia1aenBOZdtsMp_HyW5KKSg9VCh4WJLsrj1t_Wih9CAWBBFBbamXCsWqxV5c-2GlVME_093s_gvfm2R3IxRRIYTJzPucl8y8mcm8saybwqbgRzMYnajIzlEhVU45-CeAClSZR9IJApzQv3WbT9yhkzNspu_UVOavpYX5cDRaOnFfyf9YFfLArrhL9h8s2yUKGZAG-8IdLAz3v7Ix8QXRDvFcTHi6k8inCe0TjQ0V8SU4jERp4jOibMzEhEM0FFHijSOkr4hmxLMRUUEmIz4nykfEJEdLA6yJ9LHIg8sxRR7xpGGhTI5EIiADwjAiPeQF9BPuAKkY8pKAaGC0a7gDDLAQWOQViLYNQWpgKGLpotGIoUioo0fkuKFjoyLIFCXMutpIUwIRnioCimNOgShu2BWJ7s5KdkBEys0rjphUkShlJIF6UCMZKCO9SirCBYmTsqKpG4VVojUCoZasU4YVyFG1RHFDKYtnyhLbQCI5eKczIZN2FUmL7TA350rHznYvSaym9DMSmb4CBt75jN8Bj_ykPs0VDsVV9anRSYz9xdOwsz3s36KFuxIcDIpOyWlHiDz-5Dr6OBvgD1rszDo4tObgEvaeYfDJZW_dm4L7TFVvZzLLuwJDEnZ8HVcwc7ZpV_FkcyqKPHaSwBjAZHaudu8BuGVml1ytGtTuZRy66fPWuXQkNqyTz-qC1bc0e9E6U-gcgHjJuhu_34-P9uPd_bi-OdZaXm-83mysfjn-WW9v7cRrB82N5Xht-_joZfPbXvz2sPV8r7Wz2zx40aivNw7ftJ-tND_UGx8_tX-8az1dOT78HG9txN9ftZ-str5uX7amx_3pwkQuPYskFzGcoXVV3qk4IWVUVSm40EpGwqnyCi3zUMrAheauzMpRmTKHlxVOpMgIVJZKMAzB6l6x-mtztcpVa5gHeCitCmXkVqlUNJAhDIFkpKoi5PlKNGANduuodD8JOVPqmHXAGkorrZS2Q49K1cXZRePGC2A7-Cfsa9bZZEkEr-tW__zDhcoN8KnnwyHzmvwC3j-gtA |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E7%A2%B3%E7%BA%B3%E7%B1%B3%E7%AE%A1%2F%E8%81%9A%E5%90%A1%E5%92%AF%E4%BF%AE%E9%A5%B0%E7%94%B5%E6%9E%81%E7%94%A8%E4%BA%8E%E6%B6%B2%E7%9B%B8%E8%89%B2%E8%B0%B1%E6%B5%8B%E5%AE%9A%E5%B8%95%E9%87%91%E6%A3%AE%E5%A4%A7%E9%BC%A0%E8%84%91%E4%B8%AD%E7%A5%9E%E7%BB%8F%E9%80%92%E8%B4%A8&rft.jtitle=%E5%88%86%E6%9E%90%E5%8C%96%E5%AD%A6&rft.au=%E6%9E%97%E4%B8%BD+%E4%BD%99%E8%8E%89+%E6%9E%97%E7%91%9E%E6%B3%BC+%E6%9D%8E%E9%9B%AA%E7%87%95+%E6%9D%A8%E6%A0%91%E6%9E%97+%E6%9D%8E%E6%A0%A1%E5%A0%83&rft.date=2011&rft.issn=0253-3820&rft.volume=39&rft.issue=7&rft.spage=1071&rft.epage=1076&rft_id=info:doi/10.3724%2FSP.J.1096.2011.01071&rft.externalDocID=38429462 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F93919X%2F93919X.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Ffxhx%2Ffxhx.jpg |