Single-dose and multiple-dose pharmacokinetics of zaltoprofen after oral administration in healthy Chinese volunteers

• Published in: Journal of biomedical research Vol. 25; no. 1; pp. 56 - 62
• Main Authors: Li, Lingjun, Ma, Pengcheng, Cao, Yuping, Tao, Lei, Tao, Yue
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.01.2011; Editorial Department of Journal of Biomedical Research
• Subjects: nonsteroidal anti-inflammatory drug; pharmacokinetics; Research Paper; zaltoprofen; 动力学参数; 志愿者; 慢性炎症; 药代动力学; 药物剂量; 非甾体抗炎药; pharmacokinetics; zaltoprofen; nonsteroidal anti-inflammatory drug
• ISSN: 1674-8301
• DOI: 10.1016/S1674-8301(11)60007-9

Zaltoprofen, a propionic acid derivative of non-steroidal anti-inflammatory drugs, has strong inhibitory effects on actue and chronic inflammation. A randomized, dose-escalating study was conducted to evaluate the pharma-cokinetics of single and multiple oral doses of zaltoprofen in 12 healthy Chinese volunteers. Pharmacokinetics was determined from serial blood samples obtained up to 24 h after administration of a single dose of zaltoprofen at 80, 160 or 240 mg and after multiple doses of zaltqorofen at 80 mg 3 times daily. The C max and AUC 0-24 of zaltoprofen were found to be proportional to drug dose. Zaltoprofen was rapidly absorbed （t max =1.46±0.83 h） and cleared （t 1/2 =4.96±2.97 h）. Pharmacokinetic parameters after multiple doses were similar to those after single doses. Zaltoprofen was well tolerated. These results support a tid regimen of zaltoprofen for the management of acute and chronic inflammation.