Antidiabetic Potential of Commonly Available Fruit Plants in Bangladesh: Updates on Prospective Phytochemicals and Their Reported MoAs

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 24; p. 8709
• Main Authors: Alam, Safaet, Dhar, Anik, Hasan, Muhib, Richi, Fahmida Tasnim, Emon, Nazim Uddin, Aziz, Md Abdul, Mamun, Abdullah Al, Chowdhury, Md Nafees Rahman, Hossain, Md Jamal, Kim, Jin Kyu, Kim, Bonglee, Hasib, Md Sadman, Zihad, S M Neamul Kabir, Haque, Mohammad Rashedul, Mohamed, Isa Naina, Rashid, Mohammad A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2022; MDPI
• Subjects: Albinism; Antidiabetics; Antioxidants; Availability; Bangladesh; Carotenoids; Citrus fruits; Diabetes; Diabetes mellitus; Dietary minerals; Disease; Drug resistance; Flavonoids; Fruit; Fruits; Glucose; Herbal medicine; Homeopathy; Humans; Hyperglycemia; Hypoglycemic agents; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; Insulin; Insulin resistance; insulin sensitivity; Materia medica and therapeutics; Metabolic disorders; Naringenin; Phytochemicals; Phytochemicals - pharmacology; Phytochemicals - therapeutic use; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Prospective Studies; Quercetin; Review; Rutin; Seeds; Signal transduction; Therapeutics; Type 2 diabetes; α-amylase; α-glucosidase; Bangladesh; Iran; China; Malaysia; Germany; Indonesia; India; Turkey; insulin sensitivity; α-glucosidase; α-amylase; fruit; HbA1c; diabetes; insulin resistance
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27248709

Diabetes mellitus is a life-threatening disorder affecting people of all ages and adversely disrupts their daily functions. Despite the availability of numerous synthetic-antidiabetic medications and insulin, the demand for the development of novel antidiabetic medications is increasing due to the adverse effects and growth of resistance to commercial drugs in the long-term usage. Hence, antidiabetic phytochemicals isolated from fruit plants can be a very nifty option to develop life-saving novel antidiabetic therapeutics, employing several pathways and MoAs (mechanism of actions). This review focuses on the antidiabetic potential of commonly available Bangladeshi fruits and other plant parts, such as seeds, fruit peals, leaves, and roots, along with isolated phytochemicals from these phytosources based on lab findings and mechanism of actions. Several fruits, such as orange, lemon, amla, tamarind, and others, can produce remarkable antidiabetic actions and can be dietary alternatives to antidiabetic therapies. Besides, isolated phytochemicals from these plants, such as swertisin, quercetin, rutin, naringenin, and other prospective phytochemicals, also demonstrated their candidacy for further exploration to be established as antidiabetic leads. Thus, it can be considered that fruits are one of the most valuable gifts of plants packed with a wide spectrum of bioactive phytochemicals and are widely consumed as dietary items and medicinal therapies in different civilizations and cultures. This review will provide a better understanding of diabetes management by consuming fruits and other plant parts as well as deliver innovative hints for the researchers to develop novel drugs from these plant parts and/or their phytochemicals.