BNDF methylation in mothers and newborns is associated with maternal exposure to war trauma

• Published in: Clinical epigenetics Vol. 9; no. 1; pp. 68 - 12
• Main Authors: Kertes, Darlene A, Bhatt, Samarth S, Kamin, Hayley S, Hughes, David A, Rodney, Nicole C, Mulligan, Connie J
• Format: Journal Article
• Language: English
• Published: Germany BioMed Central Ltd 30.06.2017; BioMed Central; BMC
• Subjects: Aggression; Alcohol; Anxiety; BDNF; Bioinformatics; Brain research; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - blood; Brain-Derived Neurotrophic Factor - genetics; Congo; Cord blood; CpG islands; Deoxyribonucleic acid; DNA; DNA Methylation; Domestic violence; Epigenetics; Female; Fetal Blood - chemistry; Fetuses; Gene expression; Genetic aspects; Genetic Association Studies; Genomes; Health aspects; Humans; Infant, Newborn; Maternal Exposure; Maternal-fetal exchange; Neonates; Neural plasticity; Organ Specificity; Outdoor air quality; Placenta; Placenta - chemistry; Pregnancy; Prenatal; Prenatal experience; Prenatal exposure; Psychological Trauma; Stress; Studies; Synaptic plasticity; Synaptogenesis; Transcription factors; Trauma; Umbilical cord; War; War Exposure; Prenatal; Brain-derived neurotrophic factor; Placenta; BDNF; DNA methylation; War; Transcription factor; Trauma; Blood; Stress

The gene codes for brain-derived neurotrophic factor, a growth factor involved in neural development, cell differentiation, and synaptic plasticity. Present in both the brain and periphery, BDNF plays critical roles throughout the body and is essential for placental and fetal development. Rodent stu...