BNDF methylation in mothers and newborns is associated with maternal exposure to war trauma

• Published in: Clinical epigenetics Vol. 9; no. 1; pp. 68 - 12
• Main Authors: Kertes, Darlene A, Bhatt, Samarth S, Kamin, Hayley S, Hughes, David A, Rodney, Nicole C, Mulligan, Connie J
• Format: Journal Article
• Language: English
• Published: Germany BioMed Central Ltd 30.06.2017; BioMed Central; BMC
• Subjects: Aggression; Alcohol; Anxiety; BDNF; Bioinformatics; Brain research; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - blood; Brain-Derived Neurotrophic Factor - genetics; Congo; Cord blood; CpG islands; Deoxyribonucleic acid; DNA; DNA Methylation; Domestic violence; Epigenetics; Female; Fetal Blood - chemistry; Fetuses; Gene expression; Genetic aspects; Genetic Association Studies; Genomes; Health aspects; Humans; Infant, Newborn; Maternal Exposure; Maternal-fetal exchange; Neonates; Neural plasticity; Organ Specificity; Outdoor air quality; Placenta; Placenta - chemistry; Pregnancy; Prenatal; Prenatal experience; Prenatal exposure; Psychological Trauma; Stress; Studies; Synaptic plasticity; Synaptogenesis; Transcription factors; Trauma; Umbilical cord; War; War Exposure; Prenatal; Brain-derived neurotrophic factor; Placenta; BDNF; DNA methylation; War; Transcription factor; Trauma; Blood; Stress
• ISSN: 1868-7075; 1868-7083; 1868-7083; 1868-7075
• DOI: 10.1186/s13148-017-0367-x

The gene codes for brain-derived neurotrophic factor, a growth factor involved in neural development, cell differentiation, and synaptic plasticity. Present in both the brain and periphery, BDNF plays critical roles throughout the body and is essential for placental and fetal development. Rodent studies show that early life stress, including prenatal stress, broadly alters methylation, with presumed changes in gene expression. No studies have assessed prenatal exposure to maternal traumatic stress and methylation in humans. This study examined associations of prenatal exposure to maternal stress and methylation at CpG sites across the gene. Among 24 mothers and newborns in the eastern Democratic Republic of Congo, a region with extreme conflict and violence to women, maternal experiences of war trauma and chronic stress were associated with methylation in umbilical cord blood, placental tissue, and maternal venous blood. Associations of maternal stress and methylation showed high tissue specificity. The majority of significant associations were observed in putative transcription factor binding regions. This is the first study in humans to examine methylation in relation to prenatal exposure to maternal stress in three tissues simultaneously and the first in any mammalian species to report associations of prenatal stress and methylation in placental tissue. The findings add to the growing body of evidence highlighting the importance of considering epigenetic effects when examining the impacts of trauma and stress, not only for adults but also for offspring exposed via effects transmitted before birth.