High intrinsic oxidative stress may underlie selective vulnerability of the hippocampal CA1 region
Oxidative stress (OS) causes extensive cell death in the CA1 but not the CA3 region of the hippocampus. We found that the CA1 region of hippocampus explants, cultured under normal conditions, had significantly higher superoxide levels and expressed both anti-oxidant genes and genes related to the ge...
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| Published in | Brain research. Molecular brain research. Vol. 140; no. 1; pp. 120 - 126 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
31.10.2005
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0169-328X 1872-6941 |
| DOI | 10.1016/j.molbrainres.2005.07.018 |
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| Abstract | Oxidative stress (OS) causes extensive cell death in the CA1 but not the CA3 region of the hippocampus. We found that the CA1 region of hippocampus explants, cultured under normal conditions, had significantly higher superoxide levels and expressed both anti-oxidant genes and genes related to the generation of reactive oxygen species at significantly higher levels than the CA3. These observations were indicative of high intrinsic OS in CA1. |
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| AbstractList | Oxidative stress (OS) causes extensive cell death in the CA1 but not the CA3 region of the hippocampus. We found that the CA1 region of hippocampus explants, cultured under normal conditions, had significantly higher superoxide levels and expressed both anti-oxidant genes and genes related to the generation of reactive oxygen species at significantly higher levels than the CA3. These observations were indicative of high intrinsic OS in CA1. Oxidative stress (OS) causes extensive cell death in the CA1 but not the CA3 region of the hippocampus. We found that the CA1 region of hippocampus explants, cultured under normal conditions, had significantly higher superoxide levels and expressed both anti-oxidant genes and genes related to the generation of reactive oxygen species at significantly higher levels than the CA3. These observations were indicative of high intrinsic OS in CA1.Oxidative stress (OS) causes extensive cell death in the CA1 but not the CA3 region of the hippocampus. We found that the CA1 region of hippocampus explants, cultured under normal conditions, had significantly higher superoxide levels and expressed both anti-oxidant genes and genes related to the generation of reactive oxygen species at significantly higher levels than the CA3. These observations were indicative of high intrinsic OS in CA1. |
| Author | Wang, Xinkun Pal, Ranu Chen, Xue-wen Kumar, Keshava N. Limpeanchob, Nanteetip Michaelis, Elias K. |
| Author_xml | – sequence: 1 givenname: Xinkun surname: Wang fullname: Wang, Xinkun organization: Center for Neurobiology and Immunology Research, Higuchi Biosciences Center, 2099 Constant Avenue, The University of Kansas, Lawrence, KS 66047, USA – sequence: 2 givenname: Ranu surname: Pal fullname: Pal, Ranu organization: Department of Pharmacology and Toxicology, 1251 Wescoe Dr., University of Kansas, Lawrence, KS 66045, USA – sequence: 3 givenname: Xue-wen surname: Chen fullname: Chen, Xue-wen organization: Department of Electrical Engineering and Computer Science, The University of Kansas, Lawrence, KS 66045, USA – sequence: 4 givenname: Nanteetip surname: Limpeanchob fullname: Limpeanchob, Nanteetip organization: Department of Pharmacology and Toxicology, 1251 Wescoe Dr., University of Kansas, Lawrence, KS 66045, USA – sequence: 5 givenname: Keshava N. surname: Kumar fullname: Kumar, Keshava N. organization: Center for Neurobiology and Immunology Research, Higuchi Biosciences Center, 2099 Constant Avenue, The University of Kansas, Lawrence, KS 66047, USA – sequence: 6 givenname: Elias K. surname: Michaelis fullname: Michaelis, Elias K. email: emichaelis@ku.edu organization: Center for Neurobiology and Immunology Research, Higuchi Biosciences Center, 2099 Constant Avenue, The University of Kansas, Lawrence, KS 66047, USA |
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| Keywords | DHE Disorders of the nervous system Oxidative stress ALS DQ CA1 CA3 Nrf2 Nf1 Selective vulnerability GST12-12 UGT1A6 Nqo1 Txnrd1/2 AD NFκB OS GST1 MAPK γ-ECS ARE PD ROS PI Hippocampus Central nervous system CAI Encephalon |
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| Snippet | Oxidative stress (OS) causes extensive cell death in the CA1 but not the CA3 region of the hippocampus. We found that the CA1 region of hippocampus explants,... |
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| SubjectTerms | Animals Antioxidants - metabolism Biological and medical sciences CA1 CA3 Cells, Cultured Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - cytology Hippocampus - physiology Male Nrf2 Organ Culture Techniques Oxidative stress Oxidative Stress - physiology Pyramidal Cells - chemistry Pyramidal Cells - physiology Rats Rats, Sprague-Dawley Selective vulnerability Superoxides - metabolism Vertebrates: nervous system and sense organs |
| Title | High intrinsic oxidative stress may underlie selective vulnerability of the hippocampal CA1 region |
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