High intrinsic oxidative stress may underlie selective vulnerability of the hippocampal CA1 region

• Published in: Brain research. Molecular brain research. Vol. 140; no. 1; pp. 120 - 126
• Main Authors: Wang, Xinkun, Pal, Ranu, Chen, Xue-wen, Limpeanchob, Nanteetip, Kumar, Keshava N., Michaelis, Elias K.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 31.10.2005; Elsevier
• Subjects: Animals; Antioxidants - metabolism; Biological and medical sciences; CA1; CA3; Cells, Cultured; Fundamental and applied biological sciences. Psychology; Hippocampus; Hippocampus - cytology; Hippocampus - physiology; Male; Nrf2; Organ Culture Techniques; Oxidative stress; Oxidative Stress - physiology; Pyramidal Cells - chemistry; Pyramidal Cells - physiology; Rats; Rats, Sprague-Dawley; Selective vulnerability; Superoxides - metabolism; Vertebrates: nervous system and sense organs; DHE; Disorders of the nervous system; Oxidative stress; ALS; DQ; CA1; CA3; Nrf2; Nf1; Selective vulnerability; GST12-12; UGT1A6; Nqo1; Txnrd1/2; AD; NFκB; OS; GST1; MAPK; γ-ECS; ARE; PD; ROS; PI; Hippocampus; Central nervous system; CAI; Encephalon
• ISSN: 0169-328X; 1872-6941
• DOI: 10.1016/j.molbrainres.2005.07.018

Oxidative stress (OS) causes extensive cell death in the CA1 but not the CA3 region of the hippocampus. We found that the CA1 region of hippocampus explants, cultured under normal conditions, had significantly higher superoxide levels and expressed both anti-oxidant genes and genes related to the generation of reactive oxygen species at significantly higher levels than the CA3. These observations were indicative of high intrinsic OS in CA1.