Comparing surgical interventions for intertrochanteric hip fracture by blood loss and operation time: a network meta-analysis

• Published in: Journal of orthopaedic surgery and research Vol. 13; no. 1; p. 157
• Main Authors: Hao, Zhengan, Wang, Xifeng, Zhang, Xingqun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.06.2018; BioMed Central; BMC
• Subjects: Bayes Theorem; Bayesian analysis; Blood; Blood Loss, Surgical; Clinical trials; Complications and side effects; Compression; Femur; Fracture Fixation, Internal - instrumentation; Fracture Fixation, Internal - methods; Fractures; Hip; Hip Fractures - surgery; Hip joint; Humans; Internal fixation in fractures; Intertrochanteric hip fracture; Joint and ligament injuries; Meta-analysis; Methods; Network Meta-Analysis; Operative Time; Orthopedics; Randomized Controlled Trials as Topic; Review; Statistical analysis; Studies; Surgery; Surgical intervention; Systematic review; Treatment Outcome; Intertrochanteric hip fracture; Surgical intervention; Meta-analysis
• ISSN: 1749-799X; 1749-799X
• DOI: 10.1186/s13018-018-0852-8

Multiple operative treatments are available for the fixation of intertrochanteric femoral fractures. This analysis was conducted to provide guidance on the appropriate clinical choice to accommodate individual patients. A systematic review was performed to identify relevant articles in databases. Randomized controlled trials (RCTs) of adults with intertrochanteric femoral fractures were eligible if they compared 2 or more of the following interventions: proximal femoral nail anti-rotation (PFNA), percutaneous compression plate (PCCP) use, dynamic hip screw (DHS) fixation, gamma nail (GN) fixation, and artificial femoral head replacement (FHR). Bayesian network meta-analysis was performed to simultaneously compare all treatment methods. In total, 24 active-comparator studies involving 3097 participants were identified. Across all populations, greater reductions in blood loss and operation time were observed for PFNA than for other treatments. In terms of bleeding, more blood loss was observed for DHS use than for the PFNA (SMD, 1.96; 95% CI, 1.01-1.96), PCCP (SMD, 1.26; 95% CI, 0.31-2.20), and GN (SMD, 0.26; 95% CI, - 0.35-0.87) techniques. However, a more beneficial effect was observed for DHS use than for FHR (SMD, - 0.23; 95% CI, - 1.26-0.81). DHS use resulted in a significantly longer duration of operation time than the PFNA (SMD, 0.75; 95% CI, - 0.02-0.75), PCCP (SMD, 0.61; 95% CI, - 0.20-1.44), and GN (SMD, 0.25; 95% CI, - 0.26-0.77) techniques. Similarly, greater reductions in operation time were observed for DHS use than for FHR (SMD, - 0.12; 95% CI, - 1.15-0.91). The findings provide supporting evidence demonstrating the superiority of PFNA over other treatments for intertrochanteric femoral fracture. PFNA treatment results in the lowest amount of blood loss and the shortest operation time. These findings add to the existing knowledge of intertrochanteric femoral fracture treatment options.