Mean platelet volume is associated with disease severity in patients with obstructive sleep apnea syndrome

• Published in: Clinics (São Paulo, Brazil) Vol. 70; no. 7; pp. 481 - 485
• Main Authors: Akyol, Selahattin, Çörtük, Mustafa, Baykan, Ahmet Oytun, Kiraz, Kemal, Börekçi, Abdurrezzak, Şeker, Taner, Gür, Mustafa, Çayli, Murat
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Elsevier España, S.L.U 01.07.2015; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo; Faculdade de Medicina / USP; Elsevier España
• Subjects: Apnea-hypopnea index; C-Reactive Protein - analysis; Cardiovascular Diseases; Clinical Science; Female; High sensitivity C-reactive protein; Humans; Male; Mean Platelet Volume; MEDICINE, GENERAL & INTERNAL; Middle Aged; Obstructive sleep apnea; Platelet Count; Polysomnography; Prospective Studies; Risk Factors; Severity of Illness Index; Sleep Apnea, Obstructive - blood; Sleep Apnea, Obstructive - diagnosis; Mean platelet volume; High sensitivity C-reactive protein; Obstructive sleep apnea; Apnea-hypopnea index
• ISSN: 1807-5932; 1980-5322; 1980-5322
• DOI: 10.6061/clinics/2015(07)04

Obstructive sleep apnea syndrome is associated with cardiovascular diseases and thromboembolic events. The mean platelet volume (MPV) is a predictor of cardiovascular thromboembolic events. The aim of the present study is to investigate the association between the MPV and disease severity in patients with obstructive sleep apnea syndrome. We prospectively included 194 obstructive sleep apnea syndrome patients without cardiovascular disease (mean age 56.5±12.5 years) who were undergoing sleep tests. An overnight full laboratory polisomnography examination was conducted on each patient. The patients were divided into 3 groups according to the apnea-hypopnea index (AHI): (1) AHIlow group: 5≤AHI<15, (2) AHImid group: 15<AHI≤30, and (3) AHIhigh group: AHI>30. The highest MPV values were found in the AHIhigh group compared with other groups (p<0.05 for all). Multiple linear regression analysis indicated that the MPV was associated with the AHI (β=0.500, p<0.001) and the high sensitivity C-reactive protein (hs-CRP) level (β=0.194, p=0.010). The MPV is independently associated with both disease severity and inflammation in patients with obstructive sleep apnea syndrome.