Long-term quality of life and nutrition status of the aboral pouch reconstruction after total gastrectomy for gastric cancer: a prospective multicenter observational study (CCOG1505)

• Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Vol. 22; no. 3; pp. 607 - 616
• Main Authors: Tanaka, Chie, Kanda, Mitsuro, Murotani, Kenta, Yoshikawa, Takaki, Cho, Haruhiko, Ito, Yuichi, Matsui, Takanori, Nakayama, Hiroshi, Yamada, Takanobu, Kobayashi, Daisuke, Fujiwara, Michitaka, Kodera, Yasuhiro
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.05.2019; Springer Nature B.V
• Subjects: Abdominal Surgery; Body composition; Body mass; Body weight; Cancer Research; Diarrhea; Gastrectomy; Gastric cancer; Gastroenterology; Lean body mass; Medicine; Medicine & Public Health; Nutritional status; Observational studies; Oncology; Original Article; Quality of life; Questionnaires; Surgery; Surgical Oncology; Total gastrectomy; Gastric cancer; Body composition; Aboral pouch; Quality of life
• ISSN: 1436-3291; 1436-3305
• DOI: 10.1007/s10120-018-0893-z

Background Several efforts have been made to alleviate harms and symptoms after gastrectomy for gastric cancer. We previously conducted a randomized controlled trial (CCOG1101) to compare quality of life (QOL) and nutritional status between Roux-en-Y (RY) and aboral pouch (AP) reconstructions for up to 1 year after total gastrectomy. However, long-term outcomes after AP reconstruction remain unclear. Methods A prospective multicenter observational study was conducted to compare QOL, body composition, and nutritional indicators between the RY and AP reconstructions at 5 years after surgery among patients who were enrolled in the CCOG1101 trial. QOL was assessed by the PGSAS-37 questionnaires as well as the EORTC QLQ-C30 and STO22. Results Sixty patients (31 for RY and 29 for AP) were recruited for analysis. There were no significant differences in baseline and perioperative characteristics between the two groups. No significant differences were found in the EORTC QLQ-C30 global health status and functional scales. Regarding symptom scales in the QLQ-C30 and STO22, a more favorable score for the diarrhea scale was observed in the AP group. Diarrhea was also the only item in the PGSAS-37 questionnaires in which significant benefit of AP was observed. Body weight and lean body mass continued to decrease throughout the postoperative 5 years in both groups. None of the conventional nutritional indicators using the serum samples showed significant difference between the two groups. Conclusions Long-term observation suggested little benefit of AP reconstruction after total gastrectomy other than in alleviating diarrhea.