Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection

Acinetobacter baumannii ( A. baumannii ) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protein A (OmpA), a major component of outer membrane proteins (OMPs) in GNB, is a key virul...

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Published inJournal of biomedical science Vol. 27; no. 1; pp. 26 - 8
Main Authors Nie, Dan, Hu, Yue, Chen, Zhou, Li, Mingkai, Hou, Zheng, Luo, Xiaoxing, Mao, Xinggang, Xue, Xiaoyan
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 18.01.2020
BioMed Central
BMC
Subjects
A. baumannii
AbOmpA
Acinetobacter baumannii
Amino acids
Antibiotic resistance
Antibiotics
Apoptosis
Bacteria
Biofilms
Cytochrome
Drug resistance
Drug resistance in microorganisms
E coli
Gram-negative bacteria
Health aspects
Immunomodulation
Infection
Membrane proteins
Membranes
Mitochondria
Mortality
Multidrug-resistant
Nosocomial infection
Nosocomial infections
Opportunist infection
Outer membrane proteins
Pathogenesis
Pneumonia
Protein A
Proteins
Researchers
Review
Sulbactam
Therapeutic applications
Therapeutic target
Virulence
Virulence (Microbiology)
Virulence factors
Infection
Multidrug-resistant
AbOmpA
A. baumannii
Therapeutic target
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Summary:Acinetobacter baumannii ( A. baumannii ) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protein A (OmpA), a major component of outer membrane proteins (OMPs) in GNB, is a key virulence factor which mediates bacterial biofilm formation, eukaryotic cell infection, antibiotic resistance and immunomodulation. The characteristics of OmpA in Escherichia coli ( E. coli ) have been extensively studied since 1974, but only in recent years researchers started to clarify the functions of OmpA in A. baumannii . In this review, we summarized the structure and functions of OmpA in A. baumannii (AbOmpA), collected novel therapeutic strategies against it for treating A. baumannii infection, and emphasized the feasibility of using AbOmpA as a potential therapeutic target.
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ISSN:1423-0127
1021-7770
1423-0127
DOI:10.1186/s12929-020-0617-7