Androgen-Independent Prostate Cancer: Potential Role of Androgen and ErbB Receptor Signal Transduction Crosstalk

• Published in: Neoplasia (New York, N.Y.) Vol. 5; no. 2; pp. 99 - 109
• Main Authors: El Sheikh, Soha Salama, Domin, Jan, Abel, Paul, Stamp, Gordon, Lalani, El-Nasir
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2003; Neoplasia Press Inc; Elsevier
• Subjects: AKT; androgen receptor; Androgens - metabolism; ErbB receptors; Humans; Male; MAP Kinase Signaling System; MAPK; Models, Biological; Oncogene Proteins v-erbB - genetics; Oncogene Proteins v-erbB - metabolism; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; prostate cancer; Prostatic Neoplasms - pathology; Receptors, Androgen - metabolism; Review; Signal Transduction; AR; prostate cancer; androgen receptor; PC; AI; PIP3; AKT; ErbB receptors; MAPK; MAB
• ISSN: 1476-5586; 1522-8002; 1476-5586
• DOI: 10.1016/S1476-5586(03)80001-5

In prostate cancer (PC), increasing evidence suggests that androgen receptor (AR) signalling is functional under conditions of maximal androgen blockade. PC cells survive and proliferate in the altered hormonal environment possibly by interactions between growth factor-activated pathways and AR signalling. The present review article summarizes the current evidence of this crosstalk and focuses on the interactions among the ErbB receptor network, its downstream pathways, the AR. The potential role of this crosstalk in the development of androgen independence and in relation to antiandrogen therapy is discussed. Such interactions provide insight into possible complementary or additional strategies in the management of PC.