Green tea extract catechin improves cardiac function in pediatric cardiomyopathy patients with diastolic dysfunction

• Published in: Journal of biomedical science Vol. 26; no. 1; p. 32
• Main Authors: Quan, Junjun, Jia, Zhongli, Lv, Tiewei, Zhang, Lei, Liu, Lingjuan, Pan, Bo, Zhu, Jing, Gelb, Ira J, Huang, Xupei, Tian, Jie
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.05.2019; BioMed Central; BMC
• Subjects: Analysis; Calcium; Calcium ions; Cardiac function; Cardiomyopathy; Cardiovascular disease; Catechin; Composition; Congenital diseases; Demographic aspects; Desensitization; Diagnosis; Diastolic dysfunction; Echocardiography; EKG; Electrocardiography; Family medical history; Feature extraction; Gene sequencing; Green tea; Green tea extract catechin; Health aspects; Heart; Heart failure; Heart murmurs; Hypertrophic cardiomyopathy; Kinases; Laboratories; Laboratory tests; Metabolism; Mutation; Myocardial diseases; Next-generation sequencing; Patients; Pediatrics; Peptides; Prognosis; Relaxation time; Restrictive cardiomyopathy; Side effects; Stroke volume; Tea; Ventricle; Wall thickness; Netherlands; China; Hypertrophic cardiomyopathy; Restrictive cardiomyopathy; Diastolic dysfunction; Green tea extract catechin
• ISSN: 1423-0127; 1021-7770; 1423-0127
• DOI: 10.1186/s12929-019-0528-7

Our previous studies have demonstrated that Ca desensitizing catechin could correct diastolic dysfunction in experimental animals with restrictive cardiomyopathy. In this study, it is aimed to assess the effects of green tea extract catechin on cardiac function and other clinical features in pediatric patients with cardiomyopathies. Twelve pediatric cardiomyopathy patients with diastolic dysfunction were enrolled for the study. Echocardiography, ECG, and laboratory tests were performed before and after the catechin administration for 12 months. Comparison has been made in these patients before and after the treatment with catechin. Next Generation Sequencing was conducted to find out the potential causative gene variants in all patients. A significant decrease of isovolumetric relaxation time (115 ± 46 vs 100 ± 42 ms, P = 0.047 at 6 months; 115 ± 46 vs 94 ± 30 ms, P = 0.033 at 12 months), an increase of left ventricle end diastolic volume (40 ± 28 vs 53 ± 28 ml, P = 0.028 at 6 months; 40 ± 28 vs 48 ± 33 ml, P = 0.011 at 12 months) and stroke volume (25 ± 16 vs 32 ± 17 ml, P = 0.022 at 6 months; 25 ± 16 vs 30 ± 17 ml, P = 0.021 at 12 months) were observed with echocardiography in these patients 6-month after the treatment with catechin. Ejection fraction, left ventricular wall thickness, biatrial dimension remained unchanged. No significant side effects were observed in the patients tested. This study indicates that Ca desensitizing green tea extract catechin, is helpful in correcting the impaired relaxation in pediatric cardiomyopathy patients with diastolic dysfunction.