Nucleus segmentation across imaging experiments: the 2018 Data Science Bowl

Segmenting the nuclei of cells in microscopy images is often the first step in the quantitative analysis of imaging data for biological and biomedical applications. Many bioimage analysis tools can segment nuclei in images but need to be selected and configured for every experiment. The 2018 Data Sc...

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Published inNature methods Vol. 16; no. 12; pp. 1247 - 1253
Main Authors Caicedo, Juan C, Goodman, Allen, Karhohs, Kyle W, Cimini, Beth A, Ackerman, Jeanelle, Haghighi, Marzieh, Heng, CherKeng, Becker, Tim, Doan, Minh, McQuin, Claire, Rohban, Mohammad, Singh, Shantanu, Carpenter, Anne E
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.12.2019
Nature Publishing Group US
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Summary:Segmenting the nuclei of cells in microscopy images is often the first step in the quantitative analysis of imaging data for biological and biomedical applications. Many bioimage analysis tools can segment nuclei in images but need to be selected and configured for every experiment. The 2018 Data Science Bowl attracted 3,891 teams worldwide to make the first attempt to build a segmentation method that could be applied to any two-dimensional light microscopy image of stained nuclei across experiments, with no human interaction. Top participants in the challenge succeeded in this task, developing deep-learning-based models that identified cell nuclei across many image types and experimental conditions without the need to manually adjust segmentation parameters. This represents an important step toward configuration-free bioimage analysis software tools.
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ISSN:1548-7091
1548-7105
DOI:10.1038/s41592-019-0612-7