Sleep Quality and Elevated Blood Pressure in Adolescents

• Published in: Circulation (New York, N.Y.) Vol. 118; no. 10; pp. 1034 - 1040
• Main Authors: JAVAHERI, Sogol, STORFER-ISSER, Amy, ROSEN, Carol L, REDLINE, Susan
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 02.09.2008
• Subjects: Adolescent; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure; Cardiology. Vascular system; Cardiovascular system; Cross-Sectional Studies; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Female; Humans; Hypertension - etiology; Hypertension - physiopathology; Longitudinal Studies; Male; Medical sciences; Miscellaneous; Pharmacology. Drug treatments; Sleep; Sleep Deprivation - complications; Sleep Deprivation - physiopathology; Human; Hypertension; Sleep; Adolescent; pediatrics; Cardiovascular disease; Arterial pressure; Blood pressure; Sleep wake cycle; Hemodynamics; Child; Epidemiology
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circulationaha.108.766410

We assessed whether insufficient sleep is associated with prehypertension in healthy adolescents. We undertook a cross-sectional analysis of 238 adolescents, all without sleep apnea or severe comorbidities. Participants underwent multiple-day wrist actigraphy at home to provide objective estimates of sleep patterns. In a clinical research facility, overnight polysomnography, anthropometry, and 9 blood pressure measurements over 2 days were made. Exposures were actigraphy-defined low weekday sleep efficiency, an objective measure of sleep quality (low sleep efficiency < or =85%), and short sleep duration (< or =6.5 hours). The main outcome was prehypertension (> or =90th percentile for age, sex, and height), with systolic and diastolic blood pressures as continuous measures as secondary outcomes. Prehypertension, low sleep efficiency, and short sleep duration occurred in 14%, 26%, and 11% of the sample, respectively. In unadjusted analyses, the odds of prehypertension increased 4.5-fold (95% CI, 2.1 to 9.7) in adolescents with low sleep efficiency and 2.8-fold (95% CI, 1.1 to 7.3) in those with short sleep. In analyses adjusted for sex, body mass index percentile, and socioeconomic status, the odds of prehypertension increased 3.5-fold (95% CI, 1.5. 8.0) for low sleep efficiency and 2.5-fold (95% CI, 0.9 to 6.9) for short sleep. Adjusted analyses showed that adolescents with low sleep efficiency had on average a 4.0+/-1.2-mm Hg higher systolic blood pressure than other children (P<0.01). Poor sleep quality is associated with prehypertension in healthy adolescents. Associations are not explained by socioeconomic status, obesity, sleep apnea, or known comorbidities, suggesting that inadequate sleep quality is associated with elevated blood pressure.