Dosimetric comparison of library of plans and online MRI-guided radiotherapy of cervical cancer in the presence of intrafraction anatomical changes

• Published in: Radiation oncology (London, England) Vol. 14; no. 1; pp. 126 - 13
• Main Authors: Visser, J, de Boer, P, Crama, K F, van Kesteren, Z, Rasch, C R N, Stalpers, L J A, Bel, A
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.07.2019; BioMed Central; BMC
• Subjects: Adaptive; Adult; Aged; Aged, 80 and over; Anatomic Variation; Bladder; Cancer; Cancer prevention; Cancer therapies; Carcinoma, Squamous Cell - diagnostic imaging; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - radiotherapy; Care and treatment; Cervical; Cervical cancer; Chemotherapy; Diagnostic imaging; Dose Fractionation, Radiation; Dosimeters; Female; Histograms; Humans; Image Processing, Computer-Assisted - methods; Informed consent; Internet; Intestine; Intrafraction; Libraries; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Medical research; Middle Aged; MRI-guided; NMR; Nuclear magnetic resonance; Organs; Patients; Planning; Prognosis; Radiation; Radiation (Physics); Radiation therapy; Radiometry - methods; Radiotherapy; Radiotherapy Planning, Computer-Assisted - methods; Radiotherapy, Image-Guided - methods; Radiotherapy, Intensity-Modulated - methods; Registration; Retrospective Studies; Risk factors; Strategy; Uterine Cervical Neoplasms - diagnostic imaging; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - radiotherapy; Uterus; Intrafraction; Adaptive; MRI-guided; Cervical
• ISSN: 1748-717X; 1748-717X
• DOI: 10.1186/s13014-019-1322-0

Online magnetic resonance imaging (MRI)-guided radiotherapy of cervical cancer has the potential to further reduce dose to organs at risk (OAR) as compared to a library of plans (LOP) approach. This study presents a dosimetric comparison of an MRI-guided strategy with a LOP strategy taking intrafraction anatomical changes into account. The 14 patients included in this study were treated with chemo radiation at our institute and received weekly MRIs after informed consent. The MRI-guided strategy consisted of treatment plans created on the weekly sagittal MRI with 3 mm and 5 mm planning target volume (PTV) margin for clinical target volume (CTV) cervix-uterus (MRI_3mm and MRI_5mm). The plans for the LOP strategy were based on interpolations of CTV cervix-uterus on pretreatment full and empty bladder scans. Dose volume histogram (DVH) parameters were compared for targets and OARs as delineated on the weekly transversal MRI, which was acquired on average 10 min after the sagittal MRI. For the MRI_5mm strategy D of the high-risk CTV was at least 95% for all weekly MRIs of all patients, while for the LOP and MRI_3mm strategy this requirement was not satisfied for at least one weekly MRI for 1 and 3 patients, respectively. The average reduction of the volume of the reference dose (95% of the prescribed dose) as compared to the LOP strategy was 464 cm for the MRI_3mm strategy, and 422 cm for the MRI_5mm strategy. The bowel bag constraint V  < 350 cm was violated for 13 patients for the LOP strategy and for 5 patients for both MRI_3mm and MRI_5mm strategy. With online MRI-guided radiotherapy of cervical cancer considerable sparing of OARs can be achieved. If a new treatment plan can be generated and delivered within 10 min, an online MRI-guided strategy with a 5 mm PTV margin for CTV cervix-uterus is sufficient to account for intrafraction anatomical changes. NL44492.018.13.