Bisphenol A exposure and type 2 diabetes mellitus risk: a meta-analysis

• Published in: BMC endocrine disorders Vol. 18; no. 1; pp. 81 - 10
• Main Authors: Hwang, Semi, Lim, Jung-eun, Choi, Yoonjeong, Jee, Sun Ha
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.11.2018; BioMed Central; BMC
• Subjects: Benzhydryl Compounds - adverse effects; Benzhydryl Compounds - blood; Benzhydryl Compounds - urine; Bisphenol A; Bisphenol a (BPA); Blood Glucose - drug effects; Blood Glucose - metabolism; Case-Control Studies; Cross-Sectional Studies; Diabetes; Diabetes mellitus; Diabetes mellitus (DM); Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - chemically induced; Diabetes Mellitus, Type 2 - urine; Endocrine disrupting chemicals (EDCs); Environmental aspects; Environmental Exposure - adverse effects; Estrogens, Non-Steroidal - adverse effects; Estrogens, Non-Steroidal - blood; Estrogens, Non-Steroidal - urine; Fasting plasma glucose; Glucose; Health aspects; Hemoglobin; Hemoglobin A1c (HbA1c); Humans; Insulin resistance; Meta-analysis; Phenols - adverse effects; Phenols - blood; Phenols - urine; Risk factors; Sensitivity analysis; Studies; Type 2 diabetes; Type 2 diabetes mellitus (T2DM); Urine; South Korea; Hemoglobin A1c (HbA1c); Obesity; Diabetes mellitus (DM); Fasting plasma glucose; Type 2 diabetes mellitus (T2DM); Endocrine disrupting chemicals (EDCs); Bisphenol a (BPA); Meta-analysis
• ISSN: 1472-6823; 1472-6823
• DOI: 10.1186/s12902-018-0310-y

This meta-analytic study explored the relationship between the risk of type 2 diabetes mellitus (T2DM) and bisphenol A concentrations. The Embase and Medline (PubMed) databases were searched, using relevant keywords, for studies published between 1980 and 2018. A total of 16 studies, twelve cross-sectional, two case-control and one prospective, were included in the meta-analysis. The odds ratio (OR) and its 95% confidence interval (CI) were determined across the sixteen studies. The OR and its 95% CI of diabetes associated with bisphenol A were estimated using both fixed-effects and random-effects models. A total of 41,320 subjects were included. Fourteen of the sixteen studies included in the analysis provided measurements of urine bisphenol A levels and two study provided serum bisphenol A levels. Bisphenol A concentrations in human bio-specimens showed positive associations with T2DM risk (OR 1.28, 95% CI 1.14, 1.44). A sensitivity analysis indicated that urine bisphenol A concentrations were positively associated with T2DM risk (OR 1.20, 95% CI 1.09, 1.31). This meta-analysis indicated that Bisphenol A exposure is positively associated with T2DM risk in humans.