Sotrovimab therapy elicits antiviral activities against Omicron BQ.1.1 and XBB.1.5 in sera of immunocompromised patients

• Published in: Med (New York, N.Y. : Online) Vol. 4; no. 10; pp. 664 - 667
• Main Authors: Bruel, Timothée, Vrignaud, Lou-Léna, Porrot, Françoise, Planas, Delphine, Puech, Julien, Munier, Sandie, Soulié, Cathia, Zafilaza, Karen, Molino, Diana, Péré, Hélène, Yordanov, Youri, Veyer, David, Carrat, Fabrice, Schwartz, Olivier, Marcelin, Anne-Geneviève, Giraud, Valentin, Cazenave-Roblot, Fance, Martellosio Anne-Marie Ronchetti, Jean-Philippe, Gabas, Thomas, Housset, Pierre, Pardon, Agathe, Faucon, Anne-Laure, Alric, Laurent, Mourguet, Morgane, Bonnet, Delphine, Delobel, Pierre, Beck, Colleen, Boumaza, Xavier, Delage, Claire, Pires, Elisabete Gomes, Cheminant, Morgane, Anthony Chauvin, Nathalie Chavarot, Cresta, Mélanie, Pélagie Thibaut, Romain Gueneau, Siguier, Martin, Faycal, Antoine, Brin, Cécile, Djebara, Siham, Sayon, Sophie, Leducq, Vincent, Malet, Isabelle, Teyssou, Elisa, Karine Lacombe, Adélie Gothland, Chiarabini, Thibault, Valin, Nadia, Boize, Julien, Thiébaud, Pierre-Clément, Moreau, Marie, Nathalie De Castro, Charlotte Billard, Denis, Blandine, Molina, Jean-Michel, André Cabié, Lucia Etheve, Cabras, Ornella, François Vincent Dubee, Sandrine Pierre, Pistone, Thierry, Desclaux, Arnaud, Festou, Benjamin, Nathan Peiffer- Smadja, Delphine Chainier, Thy, Michael, Godard, Cindy, Bouzid, Donia, Ing, Vittiaroat, Pereira, Laurent, Pavlowsky, Thomas, Boutoille, David, Deschanvres, Colin, Cailleaux, Marine, Benezit, François, Maillard, Anne, François Coustilleres, Pierre Tattevin, Vidal, Magali, Sauvat, Léo, Baronnet, Guillaume, Florence Ader, Agnès Didier, Perpoint, Thomas, Conrad, Anne, Chabert, Paul, Loubet, Paul, Mazet, Julien, Remillon, Aline, Albert Trinh-Duc, Pauline Bouquet, Philippe Petua, Patrick Rispal, Aurore Perrot, Julien Carillo, Cougoul, Pierre, Dion, Jérémie, Mathieu Blot, Odile Rauzy, Sixt, Thibault, Moretto, Florian, Charles, Carole, Sophie Circosta, Lionel Piroth, Leger, Lydia, Arulananthan, Arulvani, Lascoux, Carine, Yazdan Yazdanpanah, Leia Becam, Petrov-Sanchez, Ventzislava, Le Mestre, Soizic, Chau, Frédéric, Soltana, Brahim, Caille, Yvanie
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.10.2023; Cell Press
• Subjects: Antibodies, Monoclonal, Humanized - therapeutic use; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Humans; Immunocompromised Host; Life Sciences; Prospective Studies
• ISSN: 2666-6340; 2666-6359; 2666-6340
• DOI: 10.1016/j.medj.2023.07.007

Antibodies effective against the recent Omicron sublineages are missing. By taking advantage of a multi-centric prospective cohort of immunocompromised individuals treated for mild-to-moderate COVID-19, Bruel et al. show that administration of 500 mg of sotrovimab induces serum neutralization and antibody-dependent cellular cytotoxicity of BQ.1.1 and XBB.1.5. Therefore, sotrovimab may remain a therapeutic option against these variants. Antibodies effective against the recent Omicron sublineages are missing. By taking advantage of a multi-centric prospective cohort of immunocompromised individuals treated for mild-to-moderate COVID-19, Bruel et al. show that administration of 500 mg of sotrovimab induces serum neutralization and antibody-dependent cellular cytotoxicity of BQ.1.1 and XBB.1.5. Therefore, sotrovimab may remain a therapeutic option against these variants.