Association between the intima-media thickness of the extracranial carotid arteries and metabolic syndrome in ethnic Kyrgyzs

• Published in: BMC cardiovascular disorders Vol. 18; no. 1; p. 199
• Main Authors: Kerimkulova, Alina S, Lunegova, Olga S, Mirrakhimov, Aibek E, Abilova, Saamay S, Nabiev, Malik P, Neronova, Ksenia V, Bektasheva, Erkaiym E, Toktomamatov, Ulan M, Esenbekova, Jyldyz E, Mirrakhimov, Erkin M
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.10.2018; BioMed Central; BMC
• Subjects: Adult; Aged; Arteriosclerosis; Asian Continental Ancestry Group; Asymptomatic Diseases; Atherosclerosis; Blood pressure; Body mass index; Cardiovascular disease; Cardiovascular diseases; Carotid arteries; Carotid Arteries - diagnostic imaging; Carotid artery; Carotid Artery Diseases - diagnostic imaging; Carotid Artery Diseases - ethnology; Carotid atherosclerosis; Carotid Intima-Media Thickness; Causes of; Cholesterol; Cross-Sectional Studies; Diabetes; Dyslipidemias - ethnology; Female; Females; Health risk assessment; Humans; Hyperglycemia - ethnology; Hypertension; Hypertension - ethnology; Incidence; Intima-media; Kyrgyz; Kyrgyzstan - epidemiology; Male; Males; Metabolic syndrome; Metabolic Syndrome - diagnosis; Metabolic Syndrome - ethnology; Middle Aged; Obesity; Obesity, Abdominal - ethnology; Predictive Value of Tests; Risk Factors; Studies; Ultrasonic imaging; Ultrasound; Veins & arteries; Women; Kyrgyzstan; Metabolic syndrome; Carotid atherosclerosis; Kyrgyz; Carotid arteries; Intima-media
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-018-0935-9

It is known that atherosclerosis is the leading cause of cardiovascular disease. We aimed to study the correlation between components of metabolic syndrome (MS) and subclinical carotid atherosclerosis in a group of ethnic Kyrgyzs. In а descriptive study we assessed 144 ethnic Kyrgyzs (69 males, 75 females) aged 36-73 years (average age 51.03 ± 8.2). All participants underwent a clinical investigation and an anthropometric evaluation (weight, height, waist circumference (WC)). Abdominal obesity (АО) was confirmed at WC ≥ 94 cm in males and ≥ 88 cm in females. Fasting plasma glucose and lipid spectrum tests were performed. An ultrasound assessment of carotid intima-media thickness (IMT) was performed using a 7.5 MHz transducer (Phillips-SD 800). MS was revealed in 61 (42.4%; 47.8% in men and 37.3% in women) of the investigated patients. IMT was significantly increased with the presence of MS components in males (no components vs 2 components of MS: 0.67 ± 0.007 and 0.81 ± 0.009 respectively; р < 0.05) and females (no components vs 3 components of MS: 0.63 ± 0.007 and 0.76 ± 0.01 respectively; р < 0.01). IMT trended towards an increase in the presence of a greater number of MS components in patients with and without AO (р < 0.01). In order to identify independent factors affecting IMT we carried out a multifactorial logistic regression analysis. Arterial hypertension was found to have the greatest influence on the development of MS (OR = 3.81, p < 0.0001). In the group of ethnic Kyrgyzs, a greater number of MS components, with AO or without AO, is associated with higher carotid IMT.