Vitamin D Receptor Polymorphisms and Renal Cancer Risk in Central and Eastern Europe

• Published in: Journal of Toxicology and Environmental Health, Part A Vol. 71; no. 6; pp. 367 - 372
• Main Authors: Karami, S., Brennan, P., Hung, R. J., Boffetta, P., Toro, J., Wilson, R. T., Zaridze, D., Navratilova, M., Chatterjee, N., Mates, D., Janout, V., Kollarova, H., Bencko, V., Szeszenia-Dabrowska, N., Holcatova, I., Moukeria, A., Welch, R., Chanock, S., Rothman, N., Chow, W.-H., Moore, L. E.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Group 01.01.2008
• Subjects: Adult; Aged; Carcinoma, Renal Cell - epidemiology; Carcinoma, Renal Cell - genetics; Case-Control Studies; Europe - epidemiology; Female; Genetic Predisposition to Disease - genetics; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic - genetics; Receptors, Calcitriol - genetics; Europe
• ISSN: 1528-7394; 1087-2620
• DOI: 10.1080/15287390701798685

Previous studies investigated the role of vitamin D intake and cancer risk. The kidney is a major organ for vitamin D metabolism, activity, and calcium homeostasis; therefore, it was hypothesized that dietary vitamin D intake and polymorphisms in the vitamin D receptor (VDR) gene may modify renal cell carcinoma (RCC) risk. Three common VDR gene polymorphisms (BsmI, FokI, TaqI) were evaluated among 925 RCC cases and 1192 controls enrolled in a hospital-based case-control study conducted in Central and Eastern Europe. Overall associations with RCC risk were not observed; however, subgroup analyses revealed associations after stratification by median age of diagnosis and family history of cancer. Among subjects over 60 yr, reduced risks were observed among carriers of the f alleles in the FokI single-nuceotide polymorphism (SNP) (odds ratio [OR] = 0.61 for Ff and OR = 0.74 for ff genotypes) compared to subjects with the FF genotype (P trend = 0.04; P interaction = 0.004). Subjects with the BB BsmI genotype and a positive family history of cancer had lower risk compared to subjects with the bb allele (OR = 0.60; 95% CI: 0.33-1.1; P trend = 0.05). Genotype associations with these subgroups were not modified when dietary sources of vitamin D or calcium were considered. Additional studies of genetic variation in the VDR gene are warranted.