Life Extension in Drosophila by Feeding a Drug

We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies f...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 99; no. 2; pp. 838 - 843
Main Authors Kang, Hyung-Lyun, Benzer, Seymour, Min, Kyung-Tai
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 22.01.2002
National Acad Sciences
The National Academy of Sciences
Subjects
4-phenylbutyrate
Acetylation
Aging
Animals
Biological Sciences
Cytochromes
Drosophila
Drosophila - drug effects
Drosophila - genetics
Drosophila - physiology
Drug therapy
Female
Female animals
Gene Expression - drug effects
Genes
Genes, Insect - drug effects
Genetics
Histones
Histones - metabolism
Insects
Life expectancy
Longevity
Longevity - drug effects
Longevity - genetics
Longevity - physiology
Male
Male animals
Phenylbutyrates - pharmacology
Superoxides
Virgin females
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Summary:We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state.
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To whom reprint requests should be addressed. E-mail: mink@ninds.nih.gov.
Contributed by Seymour Benzer
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.022631999