β-Caryophyllene: A Therapeutic Alternative for Intestinal Barrier Dysfunction Caused by Obesity

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 19; p. 6156
• Main Authors: Rodríguez-Mejía, Uriel Ulises, Viveros-Paredes, Juan Manuel, Zepeda-Morales, Adelaida Sara Minia, Carrera-Quintanar, Lucrecia, Zepeda-Nuño, José Sergio, Velázquez-Juárez, Gilberto, Delgado-Rizo, Vidal, García-Iglesias, Trinidad, Camacho-Padilla, Luisa Guadalupe, Varela-Navarro, Elizabeth, Anguiano-Sevilla, Luis Alberto, Franco-Torres, Esmeralda Marisol, López-Roa, Rocio Ivette
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.09.2022; MDPI
• Subjects: Adipocytes; Animals; Anti-inflammatory agents; Bacteria; Care and treatment; Caryophyllene; Causes of; Claudin-1; Colon; Colorectal diseases; Complications and side effects; Diet; Diet, High-Fat - adverse effects; Disease Models, Animal; Dosage and administration; dysbiosis; Endotoxemia; Evaluation; Fatty acids; Fatty Acids - therapeutic use; Feces; Gastrointestinal diseases; Gastrointestinal Diseases - drug therapy; Gastrointestinal Diseases - etiology; Gene expression; Health aspects; High fat diet; Inflammation; Intestinal Barrier Function - drug effects; Intestinal microflora; Intestine; Leptin; Lipopolysaccharides; Metabolic disorders; Metabolism; Metabolites; Mice; Mice, Inbred C57BL; Microbiota; Microbiota (Symbiotic organisms); Obesity; Obesity - complications; Obesity - drug therapy; Obesity - metabolism; Physiological aspects; Polycyclic Sesquiterpenes - pharmacology; Polycyclic Sesquiterpenes - therapeutic use; Protein expression; Proteins; Secondary metabolites; Sesquiterpenes; β-caryophyllene; Mexico; β-caryophyllene; obesity; dysbiosis
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27196156

Obesity is an excessive accumulation of fat that exacerbates the metabolic and inflammatory processes. Studies associate these processes with conditions and dysregulation in the intestinal tract, increased concentrations of lipopolysaccharides (LPSs) in the blood, differences in the abundance of intestinal microbiota, and the production of secondary metabolites such as short-chain fatty acids. β-Caryophyllene (BCP) is a natural sesquiterpene with anti-inflammatory properties and with the potential purpose of fighting metabolic diseases. A diet-induced obesity model was performed in 16-week-old C57BL/6 mice administered with BCP [50 mg/kg]. A reduction in the expression of Claudin-1 was observed in the group with a high-fat diet (HFD), which was caused by the administration of BCP; besides BCP, the and decreased between the groups with a standard diet (STD) vs. HFD. Nevertheless, the use of BCP in the STD increased the expression of these with respect to fatty acids; a similar effect was observed, in the HFD group that had a decreasing concentration that was restored with the use of BCP. The levels of endotoxemia and serum leptin increased in the HFD group, while in the HFD + BCP group, similar values were found to those of the STD group, attributing the ability to reduce these in conditions of obesity.