Evidence-based guidelines for physiotherapy management of patients with multiple myeloma: study protocol

• Published in: Systematic reviews Vol. 7; no. 1; pp. 118 - 8
• Main Authors: Jeevanantham, Deepa, Rajendran, Venkadesan, Tremblay, Line, Larivière, Céline, Knight, Andrew
• Format: Journal Article
• Language: English
• Published: England BioMed Central 16.08.2018; BMC
• Subjects: Canada; Cancer therapies; Chemotherapy; Clinical medicine; Clinical Protocols - standards; Cytotoxicity; Drug dosages; Evidence-based medicine; Evidence-Based Practice; Exercise Therapy - methods; Fatigue; Fractures; Guidelines; Humans; Industrialized nations; Multiple myeloma; Multiple Myeloma - complications; Multiple Myeloma - rehabilitation; Pain; Paralysis; Physical therapy; Physiotherapy; Protocol; Quality of Life; Radiation therapy; Spinal cord; Stem cell transplantation; Stem cells; Systematic review; Systematic Reviews as Topic; Transplants & implants; Canada; Multiple myeloma; Physiotherapy; Guidelines
• ISSN: 2046-4053; 2046-4053
• DOI: 10.1186/s13643-018-0785-7

Patients with multiple myeloma (MM) are often treated with chemotherapy, radiation, and, if indicated, autologous stem cell transplant. In addition to side effects of the treatment, patients with MM often have bone pain, pathological fractures, spinal cord compressions, fatigue, and muscle weakness, which negatively impact functional performance and quality of life. Currently, there are no related guidelines for safe and effective physiotherapy (PT) management. Accordingly, the aim of the present study is to develop guidelines for effective physiotherapy management of patients with MM by systematically reviewing and evaluating the available evidence followed by a consensus process to specifically describe the research questions as detailed below. Physiotherapy management guidelines for patients with multiple myeloma will be developed based on the results of a systematic search of the following databases: US National Library of Medicine Database (PubMed), Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica Database (EMBASE), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Elton B. Stephens Co. (EBSCO), Web of Science, Database of Abstracts of Reviews of Effects (DARE), Cochrane Database of Systematic Review, and Physiotherapy Evidence Database (PEDro). All articles will be screened for inclusion and exclusion criteria. Relevant potential articles will be identified and systematically reviewed for final phase of inclusion. Two independent reviewers will systematically review and analyze the quality of identified articles using standardized assessment tools. Scientific conclusions will be drawn and recommendations will be made based on a critical appraisal process. The guideline development will also be based on the team's judgment about the overall quality of the studies and a consensus process. Draft guidelines will be developed in the form of action statements based on the strength of evidence and grades of recommendations. The draft guidelines will be reviewed internally by two independent reviewers using AGREE II and externally by a methodological expert from Evidence-Based Care - Cancer Care Ontario and will be sent to the Canadian Physiotherapy Association (CPA) for feedback from physiotherapists. PROSPERO CRD42017064056.