Associations between physical activity, sedentary behavior, and urinary oxidized guanine in colorectal cancer patients: results from the ColoCare Study

• Published in: Applied physiology, nutrition, and metabolism Vol. 45; no. 11; pp. 1306 - 1309
• Main Authors: Viskochil, Richard, Gigic, Biljana, Lin, Tengda, Skender, Stephanie, Böhm, Jürgen, Schrotz-King, Petra, Steindorf, Karen, Owen, Robert, Figueiredo, Jane C, Li, Christopher I, Siegel, Erin M, Hardikar, Sheetal, Shibata, David, Toriola, Adetunji T, Schneider, Martin, Ulrich, Alexis, Ulrich, Cornelia M, Ose, Jennifer
• Format: Journal Article
• Language: English
• Published: 1840 Woodward Drive, Suite 1, Ottawa, ON K2C 0P7 NRC Research Press 01.11.2020; Canadian Science Publishing NRC Research Press
• Subjects: 8-OHdG; accelerometer; accéléromètre; Biomarkers; cancer colorectal; Cancer patients; Care and treatment; Colorectal cancer; Development and progression; durée de la sédentarité; Exercise; Guanine; Health aspects; Health behavior; Oxidative stress; Patient outcomes; Physiological aspects; Prognosis; Sedentary behavior; sedentary time; stress oxydatif; Germany
• ISSN: 1715-5312; 1715-5320
• DOI: 10.1139/apnm-2019-0836

To determine associations between physical activity (PA), sedentary behavior (SB), and oxidative stress in colorectal cancer patients, ColoCare Study participants in Germany wore an accelerometer 6 and/or 12 months after surgery. Spearman partial correlations were used to assess associations between PA and urinary concentrations of oxidized guanine, a validated marker of oxidative stress. There were no significant associations between PA or SB and oxidized guanine in n = 76 measurements (ng/mg creatinine; r = 0.03, p = 0.76 for PA, r = –0.05, p = 0.69 for SB). Novelty Objectively measured PA was not associated with a marker of oxidative stress in colorectal cancer patients.