Pharmacological or genetic targeting of Transient Receptor Potential (TRP) channels can disrupt the planarian escape response

• Published in: PloS one Vol. 14; no. 12; p. e0226104
• Main Authors: Sabry, Ziad, Ho, Alicia, Ireland, Danielle, Rabeler, Christina, Cochet-Escartin, Olivier, Collins, Eva-Maria S
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.12.2019; Public Library of Science (PLoS)
• Subjects: Allyl isothiocyanate; Amputation; Anandamide; Animals; Antagonists; Biology and Life Sciences; Biomechanics; Cannabinoids; Capsaicin; Channels; Developmental biology; Escape behavior; Escape Reaction - drug effects; Gene expression; Gliding; Heat; Hydrogen; Hydrogen peroxide; Hydrogen Peroxide - pharmacology; Invertebrates; Isothiocyanate; Isothiocyanates - pharmacology; Latency; Life Sciences; Locomotion; Mammals; Medicine and Health Sciences; Nociception - drug effects; Organic chemistry; Pain; Pain perception; Physical Sciences; Physics; Planarians; Regulatory mechanisms (biology); Research and Analysis Methods; RNA-mediated interference; Stimuli; Transient Receptor Potential Channels - agonists; Transient Receptor Potential Channels - genetics; Transient receptor potential proteins; Turbellaria; La Jolla California; California; United States > US; Pennsylvania

In response to noxious stimuli, planarians cease their typical ciliary gliding and exhibit an oscillatory type of locomotion called scrunching. We have previously characterized the biomechanics of scrunching and shown that it is induced by specific stimuli, such as amputation, noxious heat, and extr...