Association of ACE2 polymorphisms with susceptibility to essential hypertension and dyslipidemia in Xinjiang, China

• Published in: Lipids in health and disease Vol. 17; no. 1; p. 241
• Main Authors: Pan, Yizhi, Wang, Tianyi, Li, Yanfang, Guan, Tianwang, Lai, Yanxian, Shen, Yan, Zeyaweiding, Abudurexiti, Maimaiti, Tutiguli, Li, Fang, Zhao, Haiyan, Liu, Cheng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.10.2018; BioMed Central; BMC
• Subjects: ACE2 polymorphism; Aged; Alleles; Association; Blood pressure; Cardiovascular disease; Diabetes; Dyslipidemia; Dyslipidemias; Dyslipidemias - genetics; Dyslipidemias - physiopathology; Enzymes; Essential hypertension; Essential Hypertension - genetics; Essential Hypertension - physiopathology; Female; Genes; Genetic aspects; Genetic Association Studies; Genetic polymorphisms; Genetic Predisposition to Disease; Genotype; Health risk assessment; High density lipoprotein; Hospitals; Humans; Hypertension; Hypertriglyceridemia; Ischemia; Ischemic stroke; Low density lipoprotein; Low density lipoproteins; Male; Mass spectroscopy; Metabolic disorders; Middle Aged; Peptidyl-Dipeptidase A - genetics; Physiological aspects; Polymorphism; Polymorphism, Single Nucleotide; Population; Risk factors; Single-nucleotide polymorphism; Stroke; Stroke - genetics; Stroke - physiopathology; China; Essential hypertension; ACE2 polymorphism; Association; Ischemic stroke; Dyslipidemia
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-018-0890-6

Cardiovascular benefits by reversing environmental risks factors for essential hypertension (EH) and dyslipidemia could be weaken by high genetic risk. We investigated possible associations between ACE2 polymorphisms and dyslipidemia in patients with EH. Four hundred and two hypertensive patients were enrolled in an EH group and 233 normotensive individuals were enrolled as control group from the Xinjiang region of China. Fourteen ACE2 polymorphisms were genotyped by Matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Participants carrying T allele (TT + CT) of rs2074192 (P = 0.006), rs4646155 (P = 0.030) and rs4646188 (P < 0.001), C allele (CT + CT or CC + CG) of rs4240157 (P = 0.012), rs4830542 (P = 0.020) and rs879922 (P < 0.001) and TT genotype of rs2106809 (P = 0.012) were associated with EH. Meanwhile,ACE2 SNPs also exhibited association with dyslipidemia but exhibited obvious heterogeneity. rs1978124 (TT + CT, P = 0.009), rs2106809 (TT, P = 0.045), rs233575 (CC + CT, P = 0.018), rs4646188 (CC, P = 0.011) and rs879922 (CC + CG, P = 0.003) were association with increased LDL-C (≥1.8 mmol/L). rs2106809 (CC + CT, P < 0.001), rs2285666(TT + CT, P = 0.017), rs4646142(CC + CG, P = 0.044), rs4646155(TT + CT, P < 0.001) and rs4646188(TT + CT, P = 0.033) were association with decreased HDL-C (< 1.0 mmol/L). rs2074192 (TT + CT, P = 0.012), rs4240157 (CC + CT, P = 0.027), rs4646156 (AA+AT, P = 0.007), rs4646188 (TT + CT, P = 0.005), rs4830542 (CC + CT, P = 0.047) and rs879922 (CC + CG, P = 0.001) were association with increased TC (≥5.2 mmol/L). rs2106809 (P = 0.034) and rs4646188 (P = 0.013) were associated with hypertriglyceridemia. Further, ischemic stroke was more prevalent with rs4240157 (CC + CT, P = 0.043), rs4646188 (CC + CT, P = 0.013) and rs4830542 (CC + CT, P = 0.037). In addition, rs2048683 and rs6632677 were not association with EH, dyslipidemia and ischemic stroke. The ACE2 rs4646188 variant may be a potential and optimal genetic susceptibility marker for EH, dyslipidemia and its related ischemic stroke.