Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death
The inhibitory effects of tyrosine kinase inhibitors including tyrphostins 25, 47 and 51 on Shiga toxin 1-induced cell death and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation were examined in Vero cells. Tyrphostin 47 significantly inhibited Shiga toxin 1-induced cell death and p38...
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| Published in | European Journal of Pharmacology Vol. 546; no. 1; pp. 36 - 39 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
28.09.2006
Elsevier BV Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0014-2999 1879-0712 |
| DOI | 10.1016/j.ejphar.2006.07.014 |
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| Abstract | The inhibitory effects of tyrosine kinase inhibitors including tyrphostins 25, 47 and 51 on Shiga toxin 1-induced cell death and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation were examined in Vero cells. Tyrphostin 47 significantly inhibited Shiga toxin 1-induced cell death and p38 MAPK phosphorylation. In contrast, tyrphostins 25 and 51 had no significant effect on the Shiga toxin 1-induced responses. These data indicate that Shiga toxin 1-induced cell injury occurs through a pathway sensitive to tyrphostin 47, and the target molecule for tyrphostin 47 opens up new opportunities for pharmacological intervention against Shiga toxin-producing
Escherichia coli infectious diseases. |
|---|---|
| AbstractList | The inhibitory effects of tyrosine kinase inhibitors including tyrphostins 25, 47 and 51 on Shiga toxin 1-induced cell death and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation were examined in Vero cells. Tyrphostin 47 significantly inhibited Shiga toxin 1-induced cell death and p38 MAPK phosphorylation. In contrast, tyrphostins 25 and 51 had no significant effect on the Shiga toxin 1-induced responses. These data indicate that Shiga toxin 1-induced cell injury occurs through a pathway sensitive to tyrphostin 47, and the target molecule for tyrphostin 47 opens up new opportunities for pharmacological intervention against Shiga toxin-producing Escherichia coli infectious diseases. The inhibitory effects of tyrosine kinase inhibitors including tyrphostins 25, 47 and 51 on Shiga toxin 1-induced cell death and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation were examined in Vero cells. Tyrphostin 47 significantly inhibited Shiga toxin 1-induced cell death and p38 MAPK phosphorylation. In contrast, tyrphostins 25 and 51 had no significant effect on the Shiga toxin 1-induced responses. These data indicate that Shiga toxin 1-induced cell injury occurs through a pathway sensitive to tyrphostin 47, and the target molecule for tyrphostin 47 opens up new opportunities for pharmacological intervention against Shiga toxin-producing Escherichia coli infectious diseases.The inhibitory effects of tyrosine kinase inhibitors including tyrphostins 25, 47 and 51 on Shiga toxin 1-induced cell death and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation were examined in Vero cells. Tyrphostin 47 significantly inhibited Shiga toxin 1-induced cell death and p38 MAPK phosphorylation. In contrast, tyrphostins 25 and 51 had no significant effect on the Shiga toxin 1-induced responses. These data indicate that Shiga toxin 1-induced cell injury occurs through a pathway sensitive to tyrphostin 47, and the target molecule for tyrphostin 47 opens up new opportunities for pharmacological intervention against Shiga toxin-producing Escherichia coli infectious diseases. The inhibitory effects of tyrosine kinase inhibitors including tyrphostins 25, 47 and 51 on Shiga toxin 1-induced cell death and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation were examined in Vero cells. Tyrphostin 47 significantly inhibited Shiga toxin 1-induced cell death and p38 MAPK phosphorylation. In contrast, tyrphostins 25 and 51 had no significant effect on the Shiga toxin 1-induced responses. These data indicate that Shiga toxin 1-induced cell injury occurs through a pathway sensitive to tyrphostin 47, and the target molecule for tyrphostin 47 opens up new opportunities for pharmacological intervention against Shiga toxin-producing Escherichia coli infectious diseases. |
| Author | Horie, Atsuko Ito, Katsuaki Shimono, Mariko Oshikawa, Sayaka Gunji, Yasuhiro Sonoda, Hiroko Yamasaki, Shinji Ikeda, Masahiro |
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| Keywords | Tyrosine kinase Shiga toxin Tyrosine kinase inhibitor Tyrphostin 47 p38 MAPK Toxin Enzyme Cell death Transferases Enzyme inhibitor Mitogen-activated protein kinase Protein-tyrosine kinase |
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| SubjectTerms | Animals Biological and medical sciences Cell Death Cell Death - drug effects Cercopithecus aethiops Chlorocebus aethiops Escherichia coli MAP Kinase Signaling System MAP Kinase Signaling System - drug effects Medical sciences p38 MAPK p38 Mitogen-Activated Protein Kinases p38 Mitogen-Activated Protein Kinases - metabolism Pharmacology. Drug treatments Phosphorylation Protein Kinase Inhibitors Protein Kinase Inhibitors - pharmacology Shiga Toxin Shiga Toxin - toxicity Tyrosine kinase Tyrosine kinase inhibitor Tyrphostin 47 Tyrphostins Tyrphostins - pharmacology Vero Cells |
| Title | Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death |
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