Construction and Activity Study of a Natural Antibacterial Patch Based on Natural Active Substance-Green Porous Structures

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 3; p. 1319
• Main Authors: Gao, Xiangfan, Zhou, Yuan, Gu, Jinhui, Liu, Xinping, Zhang, Zhijun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.01.2023; MDPI
• Subjects: Acids; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-Infective Agents; Antibacterial activity; Antibacterial agents; antibacterial materials; antibacterial patch; Antibiotics; Bacteria; Bacterial diseases; Bacterial Infections; Drug resistance in microorganisms; E coli; Fluorescence; Garlic; Gram-Negative Bacteria; Gram-positive bacteria; green products; Health aspects; Health risks; Humans; Infection; Infections; Medical research; Medicine, Experimental; Microbial Sensitivity Tests; Natural products; Permeability; plant porous structures; Porosity; Scanning electron microscopy; Sulfide compounds; China; plant porous structures; antibacterial materials; antibacterial patch; green products
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules28031319

Bacterial infections are a serious threat to human health, and the rapid emergence of bacterial resistance caused by the abuse of antibiotics exacerbates the seriousness of this problem. Effectively utilizing natural products to construct new antimicrobial strategies is regarded as a promising way to suppress the rapid development of bacterial resistance. In this paper, we fabricated a new type of natural antibacterial patch by using a natural active substance (allicin) as an antibacterial agent and the porous structure of the white pulp of pomelo peel as a scaffold. The antibacterial activity and mechanisms were systematically investigated by using various technologies, including the bacteriostatic circle, plate counting, fluorescence staining, and a scanning electron microscope. Both gram-positive and negative bacteria can be effectively killed by this patch. Moreover, this natural antibacterial patch also showed significant anti-skin infection activity. This study provides a green approach for constructing efficient antibacterial patches.