Lipid profiles in adolescents with and without asthma: Korea National Health and nutrition examination survey data

• Published in: Lipids in health and disease Vol. 17; no. 1; pp. 158 - 7
• Main Authors: Ko, Sun-Hye, Jeong, Jaewook, Baeg, Myong Ki, Han, Kyung-Do, Kim, Hwan Soo, Yoon, Jong-seo, Kim, Hyun Hee, Kim, Jin Tack, Chun, Yoon Hong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.07.2018; BioMed Central; BMC
• Subjects: Adolescence; Adolescent; Adolescents; Asthma; Asthma - blood; Asthma - complications; Asthma - diagnosis; Asthma - epidemiology; Blood lipids; Child; Cholesterol; Complications and side effects; Development and progression; Dyslipidemia; Dyslipidemias - blood; Dyslipidemias - complications; Dyslipidemias - diagnosis; Dyslipidemias - epidemiology; Fasting - blood; Female; High density lipoprotein; Humans; Inflammation; KNHANES; Lipids; Lipoproteins, HDL - blood; Lipoproteins, LDL - blood; Low density lipoprotein; Male; Metabolic disorders; Metabolic syndrome; Metabolic syndrome X; Nutrition; Nutrition Surveys; Odds Ratio; Outdoor air quality; Physiological aspects; Prevalence; Republic of Korea - epidemiology; Risk factors; Risk groups; Studies; Surveys; Teenagers; TG/HDL-C ratio; Triglycerides - blood; South Korea; TG/HDL-C ratio; Adolescence; Lipids; KNHANES; Asthma
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-018-0807-4

Metabolic syndrome and dyslipidemia contribute to the development of a pro-inflammatory state in asthma. However, studies investigating the association between asthma and dyslipidemia have reported conflicting results. This study aimed to uncover the relationship between asthma and lipid profiles in adolescents using a national health and nutrition survey. This cross-sectional study analyzed the 2010-2012 Korea National Health and Nutrition Examination Survey data and included 2841 subjects aged 11-18 years with fasting blood sample data. Serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels were analyzed. We compared asthma prevalence between high-risk and low-risk lipid groups. There were 123 adolescents with asthma and 2718 without asthma (controls). The TC/HDL-C ratio, LDL-C/HDL-C ratio, and non-HDL-C levels were significantly higher in the asthma group than in the non-asthma group (P < 0.05). The high-risk groups displayed significantly higher asthma prevalence with higher TC, TG, LDL-C, and non-HDL-C levels and TG/HDL-C ratio than the low-risk groups (P < 0.05). After adjusting for potential confounding factors, the high-risk groups were associated with asthma according to their higher TC levels (adjusted odds ratio, 1.69; 95% confidence interval, 1.012-2.822) and TG/HDL-C ratios (adjusted odds ratio, 1.665; 95% confidence interval, 1.006-2.756). Asthma prevalence was greater in adolescents with a high TC level and TG/HDL-C ratio. In addition to the standard lipid profile, elevated TG/HDL-C ratio can be used as a useful additional lipid measure to evaluate interactions between dyslipidemia and asthma.