Kawasaki disease: guidelines of the Italian Society of Pediatrics, part I - definition, epidemiology, etiopathogenesis, clinical expression and management of the acute phase

• Published in: Italian journal of pediatrics Vol. 44; no. 1; p. 102
• Main Authors: Marchesi, Alessandra, Tarissi de Jacobis, Isabella, Rigante, Donato, Rimini, Alessandro, Malorni, Walter, Corsello, Giovanni, Bossi, Grazia, Buonuomo, Sabrina, Cardinale, Fabio, Cortis, Elisabetta, De Benedetti, Fabrizio, De Zorzi, Andrea, Duse, Marzia, Del Principe, Domenico, Dellepiane, Rosa Maria, D'Isanto, Livio, El Hachem, Maya, Esposito, Susanna, Falcini, Fernanda, Giordano, Ugo, Maggio, Maria Cristina, Mannarino, Savina, Marseglia, Gianluigi, Martino, Silvana, Marucci, Giulia, Massaro, Rossella, Pescosolido, Christian, Pietraforte, Donatella, Pietrogrande, Maria Cristina, Salice, Patrizia, Secinaro, Aurelio, Straface, Elisabetta, Villani, Alberto
• Format: Journal Article
• Language: English
• Published: England BioMed Central 30.08.2018; BMC
• Subjects: Acute Disease; Aspirin; Cardiology; Children; Clinical trials; Coronary artery; Coronary artery abnormalities; Coronary vessels; Disease Management; Disease Progression; Epidemiology; Female; Heart surgery; Humans; Immunoglobulins; Immunoglobulins, Intravenous - administration & dosage; Intravenous administration; Intravenous immunoglobulin; Italy; Kawasaki disease; Male; Mucocutaneous lymph node syndrome; Mucocutaneous Lymph Node Syndrome - diagnosis; Mucocutaneous Lymph Node Syndrome - epidemiology; Mucocutaneous Lymph Node Syndrome - therapy; Pediatrics; Pediatrics - standards; Practice Guidelines as Topic; Prognosis; Randomized Controlled Trials as Topic; Retrospective Studies; Review; Rheumatic diseases; Rheumatology; Risk Assessment; Severity of Illness Index; Societies, Medical; Treatment Outcome; Veins & arteries; Italy; Intravenous immunoglobulin; Aspirin; Coronary artery abnormalities; Kawasaki disease; Children
• ISSN: 1824-7288; 1720-8424; 1824-7288
• DOI: 10.1186/s13052-018-0536-3

The primary purpose of these practical guidelines related to Kawasaki disease (KD) is to contribute to prompt diagnosis and appropriate treatment on the basis of different specialists' contributions in the field. A set of 40 recommendations is provided, divided in two parts: the first describes the definition of KD, its epidemiology, etiopathogenetic hints, presentation, clinical course and general management, including treatment of the acute phase, through specific 23 recommendations.Their application is aimed at improving the rate of treatment with intravenous immunoglobulin and the overall potential development of coronary artery abnormalities in KD. Guidelines, however, should not be considered a norm that limits treatment options of pediatricians and practitioners, as treatment modalities other than those recommended may be required as a result of peculiar medical circumstances, patient's condition, and disease severity or complications.