Susceptibility to Infectious Diseases Based on Antimicrobial Peptide Production

In the last few years, the great impact of antimicrobial peptides on infectious disease susceptibility and natural resistance has been reported. In some cases, susceptibility to diseases is related to antimicrobial peptide polymorphisms and gene copy numbers, but for the vast majority of infectious...

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Bibliographic Details
Published inInfection and Immunity Vol. 77; no. 11; pp. 4690 - 4695
Main Authors Rivas-Santiago, Bruno, Serrano, Carmen J, Enciso-Moreno, J. Antonio
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.11.2009
American Society for Microbiology (ASM)
Subjects
Animals
Antimicrobial Cationic Peptides - genetics
Antimicrobial Cationic Peptides - immunology
Biological and medical sciences
Communicable Diseases - genetics
Communicable Diseases - immunology
Fundamental and applied biological sciences. Psychology
Genetic Predisposition to Disease
Humans
Microbiology
Minireview
Infection
Sensitivity
Microbiology
Peptides
Immunity
Antimicrobial agent
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Summary:In the last few years, the great impact of antimicrobial peptides on infectious disease susceptibility and natural resistance has been reported. In some cases, susceptibility to diseases is related to antimicrobial peptide polymorphisms and gene copy numbers, but for the vast majority of infectious diseases, these phenomena need to be elucidated. This review is focused on the current knowledge about susceptibility and resistance conferred by genetic variations in antimicrobial peptide expression in infectious diseases.
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Editor: J. B. Kaper
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.01515-08