Anticancer Effects of Propolis Extracts Obtained with the Cold Separation Method on PC-3 and DU-145 Prostate Cancer Cell Lines

Plant extracts are increasingly tested for their biological activity and interactions with neoplastic cells. One of such sources of biologically active substances is propolis. This product has been known for thousands of years and is widely used in alternative, folk medicine. Articles describing its...

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Published inMolecules (Basel, Switzerland) Vol. 27; no. 23; p. 8245
Main Authors Gogacz, Marek, Peszke, Jerzy, Natorska-Chomicka, Dorota, Makuch-Kocka, Anna, Dos Santos Szewczyk, Katarzyna
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 26.11.2022
MDPI
Subjects
Androgens
Antigens
Apoptosis
Biological activity
Biological products
Cancer
Care and treatment
Cell Line
Cell Proliferation
Cell signaling
Cellular signal transduction
Cold
cold separation
Gene expression
Growth factors
Health promotion
Hormones - pharmacology
Humans
Kinases
Male
Metabolism
Metastasis
Methods
Mutation
Phosphorylation
Physiological aspects
Plant extracts
Plant Extracts - pharmacology
Propolis
Propolis - pharmacology
Prostate cancer
Prostatic Neoplasms - drug therapy
Proteins
Separation
Tumor cell lines
Poland
propolis
prostate cancer
cold separation
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Summary:Plant extracts are increasingly tested for their biological activity and interactions with neoplastic cells. One of such sources of biologically active substances is propolis. This product has been known for thousands of years and is widely used in alternative, folk medicine. Articles describing its effects on the metabolism and cell signaling pathways of neoplastic cells derived from different organs are also published more and more frequently. The purpose of our study was to evaluate the biological activity of propolis extract produced with the cold separation method into hormone-dependent and hormone-independent prostate cancer cell lines. In our study, the propolis extracts showed at least an inhibitory effect on the growth of PC-3 and DU-145 neoplastic cells. Our results suggest that propolis extracts obtained with the cold separation method may be considered as promising compounds for the production of health-promoting supplements.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27238245