Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial

• Published in: BMC anesthesiology Vol. 17; no. 1; p. 81
• Main Authors: Rai, Vineya Rai Hakumat, Phang, Lee Fern, Sia, Sheau Fung, Amir, Amirah, Veerakumaran, Jeyaganesh S, Kassim, Mustafa Kassim Abdulazez, Othman, Rafidah, Tah, Pei Chien, Loh, Pui San, Jailani, Mohamad Irfan Othman, Ong, Gracie
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.06.2017; BioMed Central; BMC
• Subjects: Adolescent; Adult; Aged; Albumin; Amino Acids; Biological markers; Biomarkers; Biomarkers - blood; Blood Proteins - analysis; Brain; Brain Injuries, Traumatic - diet therapy; C-Reactive Protein - analysis; Cytokines; Enteral feeding; Enteral Nutrition; Feeding; Female; Fish oils; Food, Formulated; Glutathione; Glutathione - blood; Health aspects; Health care facilities; Humans; Identification and classification; Immunological research; Immunonutrition; Infections; Inflammation; Inflammatory response; Injuries; Interleukin 6; Interleukin-6 - blood; Male; Middle Aged; Mortality; Neomune; Neurosurgery; Nutrition; Prospective Studies; Randomization; Serum Albumin - analysis; Traumatic brain injury; Young Adult; Malaysia; Biomarkers; Neomune; Immunonutrition; Traumatic brain injury; Cytokines; Enteral nutrition
• ISSN: 1471-2253; 1471-2253
• DOI: 10.1186/s12871-017-0369-4

Head injury is one of the top three diagnosis leading to intensive care unit (ICU) admission in Malaysia. There has been growing interest in using immunonutrition as a mode of modulating the inflammatory response to injury or infection with the aim of improving clinical outcome. The aim of the present study was to evaluate the effect of an immunonutrition on biomarkers (IL-6, glutathione, CRP, total protein and albumin) in traumatic brain injury patients. Thirty six patients with head injury admitted to neurosurgical ICU in University Malaya Medical Centre were recruited for this study, over a 6-month period from July 2014 to January 2015. Patients were randomized to receive either an immunonutrition (Group A) or a standard (Group B) enteral feed. Levels of biomarkers were measured at day 1, 5 and 7 of enteral feeding. Patients in Group A showed significant reduction of IL-6 at day 5 (p < 0.001) with concurrent rise in glutathione levels (p = 0.049). Patients in Group A also demonstrated a significant increase of total protein level at the end of the study (day 7). These findings indicate the potential of immunonutrition reducing cytokines and increasing antioxidant indices in patients with TBI. However, further studies incorporating patient outcomes are needed to determine its overall clinical benefits. National Medical Research Register (NMRR) ID: 14-1430-23,171. ClinicalTrials.gov identifier: NCT03166449 .