The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2'-dicarboxylic Acid

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 1; p. 129
• Main Authors: Zhang, Jie, Jiang, Tingting, Song, Xinyu, Li, Qing, Liu, Yang, Wang, Yanhua, Chi, Xiaoyan, Sun, Jie, Zhang, Liangliang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.12.2022; MDPI
• Subjects: Acids; Adenocarcinoma; anti-tumor activity; Antimitotic agents; Antineoplastic agents; Bioflavonoids; Cancer; Carboxylic acids; Cell culture; Cell cycle; Cell growth; Chemical properties; Coordination compounds; Copper; Crystal structure; Cytotoxicity; Dicarboxylic acids; Erythroleukemia; flavone-6,2′-dicarboxylic acid; Flavones; Flavonoids; Health aspects; Histamine; Infrared analysis; Infrared spectroscopy; Investigations; Ligands; Lung cancer; Melanoma; Metal ions; Morphology; Pharmaceutical research; Production processes; S phase; Single crystals; Thermogravimetric analysis; Tumor cell lines; Tumors; X ray powder diffraction; X-ray diffraction; China; crystal structure; copper; anti-tumor activity; flavone-6,2′-dicarboxylic acid
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules28010129

A novel two-dimensional copper(II) framework (LDU-1), formulated as {[Cu (L) ·2NMP}n (H L = flavone-6,2'-dicarboxylic acid, NMP = N-Methyl pyrrolidone), has been constructed under solvothermal conditions and characterized by single-crystal X-ray diffraction, infrared spectroscopy (IR), thermogravimetric analysis and powder X-ray diffraction (PXRD). In the crystal structure, the Cu(II) shows hex-coordinated with the classical Cu paddle-wheel coordination geometry, and the flavonoid ligand coordinates with the Cu(II) ion in a bidentate bridging mode. Of particular interest of LDU-1 is the presence of anti-tumor activity against three human cancer cell lines including lung adenocarcinoma(A549), Michigan cancer foundation-7 (MCF-7), erythroleukemia (K562) and murine melanoma B16F10, indicating synergistic enhancement effects between metal ions and organic linkers. A cell cycle assay indicates that LDU-1 induces cells to arrest at S phase obviously at a lower concentration.