Dissipation and Residue of Metalaxyl-M and Azoxystrobin in Scallions and Cumulative Risk Assessment of Dietary Exposure to Hepatotoxicity

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 18; p. 5822
• Main Authors: Chai, Yida, Liu, Rong, Du, Xiaoying, Yuan, Longfei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.09.2022; MDPI
• Subjects: Adolescent; Alanine - analogs & derivatives; Azoxystrobin; Chemical and Drug Induced Liver Injury; Child; Chromatography; Chromatography, Liquid - methods; Consumers; Crop diseases; Crops; cumulative risk assessment; Cytochrome; Demographic aspects; Dietary Exposure - adverse effects; Dietary Exposure - analysis; Diseases and pests; Environmental aspects; Food; Fungal diseases; Fungicides; Fungicides, Industrial - chemistry; Gas flow; Health aspects; Hepatotoxicity; High performance liquid chromatography; Humans; Liquid chromatography; Liver; Liver diseases; Mass spectrometry; Mass spectroscopy; Metalaxyl; metalaxyl-M; Pesticide Residues - analysis; Pesticides; probabilistic model; Pyrimidines; residue; Residues; Risk analysis; Risk Assessment; Risk factors; RNA polymerase; Scallions; Strobilurins; Tandem Mass Spectrometry - methods; Testing; Toxicity; China; Beijing China; United States > US; metalaxyl-M; azoxystrobin; cumulative risk assessment; probabilistic model; residue
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27185822

Metalaxyl-M and azoxystrobin have been used to control various fungal diseases on scallion and other crops. In view of the adverse toxic effects of both on the mammalian liver, it is necessary to conduct a cumulative risk assessment of their dietary exposure to consumers. The residues of metalaxyl-M and azoxystrobin on scallion were determined by a quick, easy, cheap, effective, rugged, and safe method (QuEChERS) combined with high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS). The half-lives were about 1.15 and 3.89 days, respectively, and the final residues after a seven-day harvest interval were <0.001−0.088 mg/kg and 0.190−4.687 mg/kg, respectively. The cumulative dietary risk quotient of the two fungicides to Chinese consumers calculated by the probability model is 13.94%~41.25%. According to the results of the contribution analysis, the risk posed by azoxystrobin is much greater than that of metalaxyl-M. Although metalaxyl-M and azoxystrobin do not pose a cumulative risk to Chinese consumers, the risk to children and adolescents is significantly higher than that to adults. This suggests that in future research, more consideration should be given to the cumulative risk of compounds to vulnerable groups.