The effects of streptozotocin-induced diabetes on brucellosis of rats

• Published in: FEMS immunology and medical microbiology Vol. 39; no. 3; pp. 275 - 278
• Main Authors: Yumuk, Zeki, Küçükbasmaci, Ömer, Büyükbaba Boral, Özden, Küçüker Anğ, Mine, Dundar, Volkan
• Format: Journal Article
• Language: English
• Published: Oxford, UK Elsevier B.V 05.12.2003; Blackwell Publishing Ltd; Blackwell
• Subjects: Animals; Biological and medical sciences; Blood Glucose - metabolism; Body Weight; Brucella melitensis; Brucella melitensis - growth & development; Brucellosis; Brucellosis - blood; Brucellosis - complications; Diabetes; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - complications; Drug Interactions; Fundamental and applied biological sciences. Psychology; Insulin - pharmacology; Microbiology; Organ Size; Random Allocation; Rats; Rats, Wistar; Spleen - microbiology; Statistics, Nonparametric; Streptozocin - pharmacology; Streptozotocin; Brucellosis; Diabetes; Streptozotocin; Brucella melitensis; Endocrinopathy; Antineoplastic agent; Microbiology; Rat; Diabetes mellitus; Rodentia; Infection; Vertebrata; Antibiotic; Mammalia; Immunology; Bacteriosis
• ISSN: 0928-8244; 1574-695X
• DOI: 10.1016/S0928-8244(03)00257-8

It is believed that an infection is more common and runs a more protracted course in people with diabetes. In clinical practice, it is important to be aware of these associations, as the prognosis is often dependent upon prompt recognition and appropriate treatment. To show the course of brucellosis in the diabetic state, a model of Brucella melitensis infection was used in the setting of streptozotocin-induced diabetes in rat. B. melitensis infection proceeded more severely in diabetic rats and the severity of diabetes affected the prognosis. However, no association was found between B. melitensis and insulin using in vitro and in vivo experiments. Our study illustrates that B. melitensis infection in diabetes should be taken seriously.