Chorioamnionitis: from pathogenesis to treatment

Chorioamnionitis refers to inflammation of the amniochorionic membrane, and is a significant cause of maternal and neonatal morbidity. Chorioamnionitis most often occurs as a result of ascending infection, and is commonly associated with premature rupture of the membranes. Chorioamnionitis is genera...

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Bibliographic Details
Published inClinical microbiology and infection Vol. 17; no. 9; pp. 1304 - 1311
Main Authors Czikk, M.J., McCarthy, F.P., Murphy, K.E.
Format Journal Article
LanguageEnglish
Published Oxford, UK Elsevier Ltd 01.09.2011
Blackwell Publishing Ltd
Elsevier Limited
Subjects
Antibiotic therapy
chorioamnionitis
Chorioamnionitis - etiology
Chorioamnionitis - therapy
Female
Humans
intra-amniotic infection
Medical treatment
PPROM
Pregnancy
prevention
intra-amniotic infection
chorioamnionitis
PPROM
prevention
Antibiotic therapy
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Summary:Chorioamnionitis refers to inflammation of the amniochorionic membrane, and is a significant cause of maternal and neonatal morbidity. Chorioamnionitis most often occurs as a result of ascending infection, and is commonly associated with premature rupture of the membranes. Chorioamnionitis is generally the result of a polymicrobial infection, with Ureaplasma urealyticum, Mycoplasma hominis and Gramnegative anaerobes being frequent causative organisms. The mainstay of treatment includes antimicrobial agents, antipyretics, expedition of delivery and supportive care. Further research is required to identify mechanistic pathways and early biomarkers that accurately predict women at higher risk of adverse maternal and neonatal outcomes, and that can thus lead to the development of additional treatment and prevention strategies.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1198-743X
1469-0691
DOI:10.1111/j.1469-0691.2011.03574.x