The plaque inhibitory effect of a CPC mouthrinse in a 3-day plaque accumulation model - a cross-over study

• Published in: International journal of dental hygiene Vol. 8; no. 4; pp. 269 - 275
• Main Authors: Versteeg, PA, Rosema, NAM, Hoenderdos, NL, Slot, DE, Van der Weijden, GA
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2010; Blackwell
• Subjects: Adolescent; Adult; Anti-Infective Agents, Local - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antiseptics; Biochemistry; Biological and medical sciences; Cetylpyridinium - therapeutic use; cetylpyridinium chloride; clinical trial; Comparative studies; Cross-Over Studies; Dental hygiene; dental plaque; Dental Plaque - prevention & control; Dental research; Double-Blind Method; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Female; hexetidine; Hexetidine - therapeutic use; Humans; Hygiene; Male; Medical sciences; Middle Aged; mouthrinse; Mouthwashes; Mouthwashes - therapeutic use; Non tumoral diseases; Oral hygiene; Otorhinolaryngology. Stomatology; Pharmacology. Drug treatments; Plaques; Surveys and Questionnaires; Taste; Young Adult; Stomatology; Cetylpyridinium chloride; Dental disease; Dental plaque; Hexetidine; Mouth rince; Dentistry; Accumulation; Antiprotozoal agent; Antifungal agent; Parasiticide; Clinical trial; Antibacterial agent; Disinfecting agent; mouthrinse
• ISSN: 1601-5029; 1601-5037; 1601-5037
• DOI: 10.1111/j.1601-5037.2009.00421.x

To cite this article: 
 Int J Dent Hygiene 8, 2010; 269–275
DOI: 10.1111/j.1601‐5037.2009.00421.x
Versteeg PA, Rosema NAM, Hoenderdos NL, Slot DE, Van der Weijden GA. The plaque inhibitory effect of a CPC mouthrinse in a 3‐day plaque accumulation model – a cross‐over study. :  Objective:  To test the plaque inhibitory effect of an experimental 0.07% cetylpyridinium chloride (CPC) mouthrinse in a 3‐day plaque accumulation model in a cross‐over design. Material and Methods:  A total of 30 subjects (non‐dental students), ≥18 years of age, were randomly assigned to use one of three different mouthrinses three times a day. After 3 days, the subjects returned for the clinical assessments and received a questionnaire to evaluate their attitude towards the product used by them. The cross‐over procedure was repeated twice to have all subjects use all products. Results:  A total of 29 subjects completed the protocol and this resulted in a statistically significant difference between the three groups (P < 0.001) with regard to plaque scores. Over three sessions, the mean plaque scores were 2.17 for the control product, 1.14 for the CPC group and 1.12 for the 0.1% Hexetidine product (positive control). Results of the questionnaire show that, compared with hexetidine, the taste of the CPC was appreciated better, and less oral sensations were observed following rinsing. Conclusion:  The CPC mouthrinse proved to be effective in inhibiting ‘de novo’ plaque formation to an extent similar to that of a 0.1% hexetidine product. Compared with hexetidine, the taste of the CPC was appreciated better and less oral sensations were observed following rinsing.