Cell Culture-Based Assessment of Toxicity and Therapeutics of Phytochemical Antioxidants

Plant-derived natural products are significant resources for drug discovery and development including appreciable potentials in preventing and managing oxidative stress, making them promising candidates in cancer and other disease therapeutics. Their effects have been linked to phytochemicals such a...

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Published inMolecules (Basel, Switzerland) Vol. 27; no. 3; p. 1087
Main Authors Asuzu, Peace C, Trompeter, Nicholas S, Cooper, Carlton R, Besong, Samuel A, Aryee, Alberta N A
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 06.02.2022
MDPI
Subjects
Animals
antioxidant activity
Antioxidants
Antioxidants - therapeutic use
Antioxidants - toxicity
Apoptosis
Biocompatibility
bioprinting
Cancer therapies
Cell culture
Cell growth
cell lines
Cytotoxicity
Herbal medicine
Humans
Kinases
medicinal plants
Metabolites
Natural products
Oxidative Stress
Phenolic compounds
Phenols
Phytochemicals
Phytochemicals - therapeutic use
Phytochemicals - toxicity
Plant extracts
Plant Extracts - therapeutic use
Plant Extracts - toxicity
Plants
Review
Toxicity Tests
apoptosis
medicinal plants
cell lines
antioxidant activity
bioprinting
cytotoxicity
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Abstract Plant-derived natural products are significant resources for drug discovery and development including appreciable potentials in preventing and managing oxidative stress, making them promising candidates in cancer and other disease therapeutics. Their effects have been linked to phytochemicals such as phenolic compounds and their antioxidant activities. The abundance and complexity of these bio-constituents highlight the need for well-defined in vitro characterization and quantification of the plant extracts/preparations that can translate to in vivo effects and hopefully to clinical use. This review article seeks to provide relevant information about the applicability of cell-based assays in assessing anti-cytotoxicity of phytochemicals considering several traditional and current methods.
AbstractList Plant-derived natural products are significant resources for drug discovery and development including appreciable potentials in preventing and managing oxidative stress, making them promising candidates in cancer and other disease therapeutics. Their effects have been linked to phytochemicals such as phenolic compounds and their antioxidant activities. The abundance and complexity of these bio-constituents highlight the need for well-defined in vitro characterization and quantification of the plant extracts/preparations that can translate to in vivo effects and hopefully to clinical use. This review article seeks to provide relevant information about the applicability of cell-based assays in assessing anti-cytotoxicity of phytochemicals considering several traditional and current methods.
Author Besong, Samuel A
Cooper, Carlton R
Asuzu, Peace C
Aryee, Alberta N A
Trompeter, Nicholas S
AuthorAffiliation 1 Department of Human Ecology (Food Science and Biotechnology Program), College of Agriculture, Science and Technology, Delaware State University, Dover, DE 19901, USA; pcasuzu17@students.desu.edu (P.C.A.); sbesong@desu.edu (S.A.B.)
3 Center for Translational Cancer Research, Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA; crcooper@udel.edu
2 Department of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA; ntromp@udel.edu
AuthorAffiliation_xml – name: 1 Department of Human Ecology (Food Science and Biotechnology Program), College of Agriculture, Science and Technology, Delaware State University, Dover, DE 19901, USA; pcasuzu17@students.desu.edu (P.C.A.); sbesong@desu.edu (S.A.B.)
– name: 2 Department of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA; ntromp@udel.edu
– name: 3 Center for Translational Cancer Research, Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA; crcooper@udel.edu
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  givenname: Peace C
  surname: Asuzu
  fullname: Asuzu, Peace C
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– sequence: 2
  givenname: Nicholas S
  surname: Trompeter
  fullname: Trompeter, Nicholas S
  organization: Department of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA
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  givenname: Carlton R
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  givenname: Samuel A
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  fullname: Besong, Samuel A
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  givenname: Alberta N A
  orcidid: 0000-0002-1874-9066
  surname: Aryee
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  organization: Department of Human Ecology (Food Science and Biotechnology Program), College of Agriculture, Science and Technology, Delaware State University, Dover, DE 19901, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35164354$$D View this record in MEDLINE/PubMed
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Keywords apoptosis
medicinal plants
cell lines
antioxidant activity
bioprinting
cytotoxicity
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Snippet Plant-derived natural products are significant resources for drug discovery and development including appreciable potentials in preventing and managing...
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StartPage 1087
SubjectTerms Animals
antioxidant activity
Antioxidants
Antioxidants - therapeutic use
Antioxidants - toxicity
Apoptosis
Biocompatibility
bioprinting
Cancer therapies
Cell culture
Cell growth
cell lines
Cytotoxicity
Herbal medicine
Humans
Kinases
medicinal plants
Metabolites
Natural products
Oxidative Stress
Phenolic compounds
Phenols
Phytochemicals
Phytochemicals - therapeutic use
Phytochemicals - toxicity
Plant extracts
Plant Extracts - therapeutic use
Plant Extracts - toxicity
Plants
Review
Toxicity Tests
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Title Cell Culture-Based Assessment of Toxicity and Therapeutics of Phytochemical Antioxidants
URI https://www.ncbi.nlm.nih.gov/pubmed/35164354
https://www.proquest.com/docview/2627821466
https://search.proquest.com/docview/2629056332
https://pubmed.ncbi.nlm.nih.gov/PMC8839249
https://doaj.org/article/ff121cc11e48495ab57fa4eeee4c971d
Volume 27
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