A Real-World Claims Database Study Assessing Long-Term Persistence with Golimumab Treatment in Patients with Rheumatoid Arthritis in Japan

• Published in: Rheumatology and therapy. Vol. 10; no. 3; pp. 615 - 634
• Main Authors: Miyashiro, Masahiko, Ishii, Yutaka, Miyazaki, Celine, Shimizu, Hirohito, Masuda, Junya
• Format: Journal Article
• Language: English
• Published: Cheshire Springer Healthcare 01.06.2023; Springer Nature B.V; Adis, Springer Healthcare
• Subjects: Biological products; Biologics; Clinical medicine; Cohort analysis; Disease; Drugs; Family Medicine; General Practice; Golimumab; Insurance claims; Internal Medicine; Medicine; Medicine & Public Health; Monoclonal antibodies; Original Research; Orthopedics; Patients; Persistence; Pharmaceuticals; Quality of life; Quality of Life Research; Real-world database; Rheumatoid arthritis; Rheumatology; Tumor necrosis factor-TNF; Japan; Golimumab; Persistence; Real-world database; Biologics; Rheumatoid arthritis
• ISSN: 2198-6576; 2198-6584
• DOI: 10.1007/s40744-023-00539-z

Introduction The persistence of golimumab (GLM) treatment in Japanese patients with rheumatoid arthritis (RA) has been evaluated previously, but evidence of long-term real-world use is lacking. This study assessed the long-term persistence of GLM use, its influencing factors, and impact of prior medications in patients with RA in actual clinical practice in Japan. Methods This is a retrospective cohort study of patients with RA using data from a hospital insurance claims database in Japan. The identified patients were stratified as only GLM treatment (naïve), had one biological disease-modifying anti-rheumatic drug (bDMARD)/Janus kinase (JAK) inhibitor treatment prior to GLM [switch (1)] and had at least two bDMARDs/JAK prior to GLM treatment [switch (≥ 2)]. Patient characteristics were evaluated using descriptive statistics. Kaplan–Meier survival and Cox regression methods were used to analyze GLM persistence at 1, 3, 5, and 7 years and the associated factors. Treatment differences were compared using a log-rank test. Results GLM persistence rate in the naïve group was 58.8%, 32.1%, 21.4%, and 11.4% at 1, 3, 5, and 7 years, respectively. Overall persistence rates in the naïve group were higher than in switch groups. Higher GLM persistence was observed among patients aged 61–75 years and those concomitantly using methotrexate (MTX). Also, women were less likely to discontinue treatment compared to men. Higher Charlson Comorbidity Index score, initial GLM dose of 100 mg, and switch from bDMARDs/JAK inhibitor were related to a lower persistence rate. As a prior medication, infliximab showed the longest persistence for subsequent GLM, and using this as a reference, tocilizumab, sarilumab, and tofacitinib subgroups had significantly shorter persistence, respectively ( p  = 0.001, 0.025, 0.041). Conclusion This study presents the long-term real-world results for persistence of GLM and its potential determinants. These most recent and long-term observations demonstrated that GLM and other bDMARDs continue to benefit patients with RA in Japan.