Coupling of neurogenesis and angiogenesis after ischemic stroke

• Published in: Brain research Vol. 1623; pp. 166 - 173
• Main Authors: Ruan, Linhui, Wang, Brian, ZhuGe, Qichuan, Jin, Kunlin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 14.10.2015
• Subjects: Angiogenesis; Animals; Brain Ischemia - physiopathology; Cell interaction; Humans; Ischemia; Neovascularization, Pathologic - physiopathology; Neovascularization, Physiologic - physiology; Neurogenesis; Neurogenesis - physiology; Neurology; Recovery of Function - physiology; Stroke; Stroke - physiopathology; Angiogenesis; Cell interaction; Stroke; Ischemia; Neurogenesis
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2015.02.042

Abstract Stroke is a leading cause of mortality and severe long-term disability worldwide. Development of effective treatment or new therapeutic strategies for ischemic stroke patients is therefore crucial. Ischemic stroke promotes neurogenesis by several growth factors including FGF-2, IGF-1, BDNF, VEGF and chemokines including SDF-1, MCP-1. Stroke-induced angiogenesis is similarly regulated by many factors most notably, eNOS and CSE, VEGF/VEGFR2, and Ang-1/Tie2. Important findings in the last decade have revealed that neurogenesis is not the stand-alone consideration in the fight for full functional recovery from stroke. Angiogenesis has been also shown to be critical in improving post-stroke neurological functional recovery. More than that, recent evidence has shown a highly possible interplay or dependence between stroke-induced neurogenesis and angiogenesis. Moving forward, elucidating the underlying mechanisms of this coupling between stroke-induced neurogenesis and angiogenesis will be of great importance, which will provide the basis for neurorestorative therapy. This article is part of a Special Issue entitled SI: Cell Interactions In Stroke.