Temperature Sensitivity of Two-Pore (K2P) Potassium Channels

At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Heat dramatically potentiates K2P channel activity and further affects excitation. T...

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Bibliographic Details
Published inCurrent Topics in Membranes Vol. 74; pp. 113 - 133
Main Authors Schneider, Eve R., Anderson, Evan O., Gracheva, Elena O., Bagriantsev, Sviatoslav N.
Format Book Chapter Journal Article
LanguageEnglish
Published United States Elsevier Science & Technology 2014
Subjects
Animals
Ion channel
Ion Channel Gating
K2P
Mechanical Phenomena
Potassium channel
Potassium Channels - chemistry
Potassium Channels - metabolism
Thermosensing
Thermosensitivity
Thermotransduction
TRAAK
TREK-1
TREK-2
Two-pore
TREK-2
TREK-1
Two-pore
Thermosensitivity
K2P
Thermotransduction
TRAAK
Ion channel
Potassium channel
K(2P)
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Summary:At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Heat dramatically potentiates K2P channel activity and further affects excitation. This review focuses on the current understanding of the physiological role of heat-activated K2P current, and discusses the molecular mechanism of temperature gating in TREK-1, TREK-2, and TRAAK.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISBN:9780128001813
012800181X
ISSN:1063-5823
DOI:10.1016/B978-0-12-800181-3.00005-1