Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)

• Published in: Gene Vol. 715; p. 144005
• Main Authors: Xu, Pengfei, Ianes, Chiara, Gärtner, Fabian, Liu, Congxing, Burster, Timo, Bakulev, Vasiliy, Rachidi, Najma, Knippschild, Uwe, Bischof, Joachim
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.10.2019; Elsevier
• Subjects: Animals; Biochemistry, Molecular Biology; Cancer; Casein kinase 1; Casein Kinase Idelta; Casein Kinase Idelta - antagonists & inhibitors; Casein Kinase Idelta - chemistry; Casein Kinase Idelta - genetics; Casein Kinase Idelta - metabolism; CSNK1D; Drug Delivery Systems; Drug Delivery Systems - methods; Hedgehog pathway; Humans; Isoenzymes; Isoenzymes - antagonists & inhibitors; Isoenzymes - chemistry; Isoenzymes - genetics; Isoenzymes - metabolism; Life Sciences; Microbiology and Parasitology; Neoplasm Proteins; Neoplasm Proteins - antagonists & inhibitors; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Neoplasms; Neoplasms - drug therapy; Neoplasms - enzymology; Neoplasms - genetics; Neoplasms - pathology; p53; Parasitology; Phosphorylation; Signal Transduction; Site-specific phosphorylation; Small molecule inhibitor; Stress-induced kinase; Structure-Activity Relationship; Wnt signaling pathway; SCS; BBB; CDC; ARF GAP1; Gli; Gln; HIF-1α; Phe or F; CDK; mGluR; bHLH; SRR-1; Glu; RBC; RanBPM; ABAD; Tyr or Y; Cys or C; BLAST; CCdh1; LEF-1; aa; Casein kinase 1; Rec11; AD; ppUL44; CSNK1D; β-TrCP; Small molecule inhibitor; PP1; Thr or T; mTNFα; SV40; TGN; Mam1; HPI; A; Vangl2; Dhh; Sre1N; CG-NAP; AIB1; DARPP-32; YAP; Chk1; M; Met or M; N; nm23-H1; P; R; S; NLS; Hsp90/70; Swi6; ICP0; ISC; X; Y; Wnt; Ser or S; Plk1; hnRNP A1; ENP1; N-terminus; NFTs; TEAD; STAG3; Dma1; ATM; CiA; ATP; DD; TOP2A; TV; Ci; KHD; CiR; DS; Arg or R; Shh; FAM83; PKB/Akt; ERα; LATS1/2; MAPK; PSP; MTSS1; RhoA; BACE1; TDP-43; MAPT; PCP; Phosphorylation; HTP; Site-specific phosphorylation; CPI-17; PS-2; PDC; PDB; Gly or G; DUF1669; IWP; N-lobe; Wnt signaling pathway; FTLD; GST; BYSL; NPs; GSK3β; Stress-induced kinase; NEDD4; Ci-155; Huwe1; PER; BMAL1; PET; Val; CLL; FASPS; CK1BP; Ihh; CLS; p53; TOPOII-α; IC50; Lys or K; Hh; ePK; SMI; APC/C Cdh1; BLOC-1; Smo; EB1; DPC; MAP; IFNAR1; Pro or P; TPA; Porcn; PiD; C-lobe; CREB; KD; MBP; Sid4; Vmax; Asp or D; IKK; PGC-1α; Dnmt1; MDM2; Cancer; GVBs; P-bodies; SNAP25; CPP; Km; DDX3X; Chk2/Cds1; ALS; HRII; LRP; PKD2; TAZ; eIF6/Tif6p49; Ile or I; Atoh1; Emi2; Aβ; PPND; REGγ; PKCa; MTOC; PKA; SPBs; ARNT; SV40 T-Ag; RPL4/8/13; MEF; Ptch; CAT; FoxG1; kcat; MST1/2; Leu or L; UVB; MESA; UHRF1; AKAP; LTP; CRY; dCK; NFAT1; Asn or N; CKL2; CK1α/γ1–3/δ/ε; SV2A; pThr; SMAD; Dpr1a; pSer; C-terminus; Rec8; Nop56; Hedgehog pathway; Fzd; Wee1; APC; Cx43; PD; SCF; m6A; SPRY2; Dvl
• ISSN: 0378-1119; 1879-0038; 1879-0038
• DOI: 10.1016/j.gene.2019.144005

Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles in multiple cellular processes from protozoa to human. Since their dysregulation as well as mutations within their coding regions contribute to the development of various different pathologies, including cancer and neurodegenerative diseases, they have become interesting new drug targets within the last decade. However, to develop optimized CK1 isoform-specific therapeutics in personalized therapy concepts, a detailed knowledge of the regulation and functions of the different CK1 isoforms, their various splice variants and orthologs is mandatory. In this review we will focus on the stress-induced CK1 isoform delta (CK1δ), thereby addressing its regulation, physiological functions, the consequences of its deregulation for the development and progression of diseases, and its potential as therapeutic drug target. •CK1δ (encoded by the gene CSNK1D) is a member of the CK1 family of serine/threonine specific kinases•CK1δ is induced in stress situations and connected with p53 through an autoregulatory feedback loop•CK1δ exhibits a pleiotropic character and is involved in the regulation of various cellular processes•CK1δ is tightly regulated and deregulation or mutations of CK1δ contribute to development of various diseases•CK1δ is a promising therapeutic target for the treatment of cancer and neurodegenerative diseases