Pathology and biology of radiation-induced cardiac disease

Heart disease is the leading global cause of death. The risk for this disease is significantly increased in populations exposed to ionizing radiation, but the mechanisms are not fully elucidated yet. This review aims to gather and discuss the latest data about pathological and biological consequence...

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Bibliographic Details
Published inJournal of radiation research Vol. 57; no. 5; pp. 439 - 448
Main Author Tapio, Soile
Format Journal Article
LanguageEnglish
Published England The Japanese Radiation Research Society 01.09.2016
Oxford University Press
Subjects
Animals
Apoptosis
Cellular Senescence
Exposure
Heart diseases
Heart Diseases - pathology
Humans
Ionizing radiation
Models, Biological
Oxidative Stress
Radiation damage
Radiation effects
Radiation Injuries - pathology
Review
cardiac disease
myocardium
endothelial cell
ionizing radiation
heart
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Summary:Heart disease is the leading global cause of death. The risk for this disease is significantly increased in populations exposed to ionizing radiation, but the mechanisms are not fully elucidated yet. This review aims to gather and discuss the latest data about pathological and biological consequences in the radiation-exposed heart in a comprehensive manner. A better understanding of the molecular and cellular mechanisms underlying radiation-induced damage in heart tissue and cardiac vasculature will provide novel targets for therapeutic interventions. These may be valuable for individuals clinically or occupationally exposed to varying doses of ionizing radiation.
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ISSN:0449-3060
1349-9157
1349-9157
DOI:10.1093/jrr/rrw064