A Parametric Empirical Bayesian Framework for the EEG/MEG Inverse Problem: Generative Models for Multi-Subject and Multi-Modal Integration

• Published in: Frontiers in human neuroscience Vol. 5; p. 76
• Main Authors: Henson, Richard N., Wakeman, Daniel G., Litvak, Vladimir, Friston, Karl J.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 2011
• Subjects: Bayesian analysis; Cortex; EEG; Functional magnetic resonance imaging; Inverse problems; Magnetoencephalography; Mathematical models; Neuroscience; NMR; Noise; Nuclear magnetic resonance; Pattern recognition; Sensors; Sensory integration; Signal processing; Temporal perception; data fusion; bioelectromagnetic signals; source reconstruction; neuroimaging
• ISSN: 1662-5161; 1662-5161
• DOI: 10.3389/fnhum.2011.00076

We review recent methodological developments within a parametric empirical Bayesian (PEB) framework for reconstructing intracranial sources of extracranial electroencephalographic (EEG) and magnetoencephalographic (MEG) data under linear Gaussian assumptions. The PEB framework offers a natural way to integrate multiple constraints (spatial priors) on this inverse problem, such as those derived from different modalities (e.g., from functional magnetic resonance imaging, fMRI) or from multiple replications (e.g., subjects). Using variations of the same basic generative model, we illustrate the application of PEB to three cases: (1) symmetric integration (fusion) of MEG and EEG; (2) asymmetric integration of MEG or EEG with fMRI, and (3) group-optimization of spatial priors across subjects. We evaluate these applications on multi-modal data acquired from 18 subjects, focusing on energy induced by face perception within a time-frequency window of 100-220 ms, 8-18 Hz. We show the benefits of multi-modal, multi-subject integration in terms of the model evidence and the reproducibility (over subjects) of cortical responses to faces.