Regulatory signal transduction pathways for class IIa histone deacetylases

• Published in: Current opinion in pharmacology Vol. 10; no. 4; pp. 454 - 460
• Main Authors: Parra, Maribel, Verdin, Eric
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2010
• Subjects: Brain; Calcium-Calmodulin-Dependent Protein Kinases - metabolism; Histone Deacetylases - metabolism; Humans; Immune System - physiology; Internal Medicine; Medical Education; Phosphorylation; Protein Transport; Repressor Proteins - metabolism; Signal Transduction

The class IIa histone deacetylases (HDACs), HDAC4, 5, 7, and 9, have crucial roles in the development of the immune system and other organs, including brain, heart, and muscle. In addition to their catalytic domain, they are characterized by a large amino-terminal extension. The amino-terminal domai...