Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives

A total of forty novel glycyrrhetinic acid (GA) derivatives were designed and synthesized. The cytotoxic activity of the novel compounds was tested against two human breast cancer cell lines (MCF-7, MDA-MB-231) in vitro by the MTT method. The evaluation results revealed that, in comparison with GA,...

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Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 21; no. 2; p. 199
Main Authors Li, Yang, Feng, Ling, Song, Zhi-Fang, Li, Hai-Bei, Huai, Qi-Yong
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 06.02.2016
MDPI
Subjects
Acids
anticancer
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Antitumor activity
Breast cancer
Cancer
Cell Survival - drug effects
Cytotoxicity
derivatives
Doxorubicin - pharmacology
Drug Screening Assays, Antitumor
glycyrrhetinic acid (GA)
Glycyrrhetinic Acid - analogs & derivatives
Glycyrrhetinic Acid - chemical synthesis
Glycyrrhetinic Acid - pharmacology
Humans
In vitro methods and tests
Inhibitory Concentration 50
MCF-7
MCF-7 Cells
MDA-MB-231
Tumor cell lines
derivatives
glycyrrhetinic acid (GA)
MCF-7
MDA-MB-231
anticancer
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Summary:A total of forty novel glycyrrhetinic acid (GA) derivatives were designed and synthesized. The cytotoxic activity of the novel compounds was tested against two human breast cancer cell lines (MCF-7, MDA-MB-231) in vitro by the MTT method. The evaluation results revealed that, in comparison with GA, compound 42 shows the most promising anticancer activity (IC50 1.88 ± 0.20 and 1.37 ± 0.18 µM for MCF-7 and MDA-MB-231, respectively) and merits further exploration as a new anticancer agent.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules21020199