Toxic Multinodular Goiter with Low Radioactive Iodine Uptake

A 74-year-old woman was referred to our hospital for goiter and persistent thyrotoxicosis. She had no signs of ophthalmopathy. She was not taking thyroid hormone. Thyroid CT revealed multiple nodules. The thyroid gland was not detected on 99mTc scintigraphy, 123I uptake rate was 4.5% at 24 hours wit...

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Published inInternal Medicine Vol. 50; no. 16; pp. 1709 - 1714
Main Authors Kahara, Toshio, Shimizu, Akiko, Uchiyama, Akio, Terahata, Shintaro, Tajiri, Junichi, Nishihara, Eijun, Miyauchi, Akira, Abo, Hitoshi, Sumiya, Hisashi, Ishikura, Kazuhide, Usuda, Rika, Noto, Hirofumi
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 01.01.2011
Subjects
99mtechnetium
Aged
Female
Goiter, Nodular - diagnosis
Goiter, Nodular - metabolism
Goiter, Nodular - surgery
Humans
hyperthyroidism
Iodine Radioisotopes - metabolism
radioactive iodine uptake
SPECT
thyrotoxicosis
Thyrotoxicosis - diagnosis
Thyrotoxicosis - metabolism
Thyrotoxicosis - surgery
toxic multinodular goiter
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Summary:A 74-year-old woman was referred to our hospital for goiter and persistent thyrotoxicosis. She had no signs of ophthalmopathy. She was not taking thyroid hormone. Thyroid CT revealed multiple nodules. The thyroid gland was not detected on 99mTc scintigraphy, 123I uptake rate was 4.5% at 24 hours without hot nodules, and aberrant goiter was negative. After partial thyroidectomy, she was treated with levothyroxine. TRAb was undetectable during the disease course, and focal destructive change or chronic lymphocytic thyroiditis on the pathological specimens was not evident. We report a rare case of toxic multinodular goiter with low radioactive iodine uptake.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.50.5256