The Role of Genetic Variants in the Susceptibility of Noise-Induced Hearing Loss

• Published in: Frontiers in cellular neuroscience Vol. 16; p. 946206
• Main Authors: Chen, Xue-min, Xue, Xin-miao, Yu, Ning, Guo, Wei-wei, Yuan, Shuo-long, Jiang, Qing-qing, Yang, Shi-ming
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 12.07.2022; Frontiers Media S.A
• Subjects: Apoptosis; Cellular Neuroscience; Chemokines; Cilia; Cytokines; DNA damage; DNA repair; Environmental conditions; Flow velocity; genes; Genetic diversity; Genetic factors; genetic variants; Hair; Hearing loss; Hearing protection; Heat shock proteins; Hsp70 protein; Kinases; Metabolism; Metabolites; Noise; noise prevention; noised-induced hearing loss; Oxidative stress; Pathogenesis; Population studies; Protein structure; Sound; susceptibility; Tinnitus; Tumor necrosis factor-TNF; genetic variants; noise prevention; noised-induced hearing loss; susceptibility; genes

Noised-induced hearing loss (NIHL) is an acquired, progressive neurological damage caused by exposure to intense noise in various environments including industrial, military and entertaining settings. The prevalence of NIHL is much higher than other occupational injuries in industrialized countries....